Comparative Genomic Insights Into the Biosynthesis and Regulation of Mycobacterial Siderophores
Iron is essential for nearly all biological events. Siderophores are indispensable for most organisms to obtain iron from iron-limiting milieus. This holds particularly true for pathogens such as the causative agent of tuberculosis – Mycobacterium tuberculosis. The categories of mycobacterial sidero...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Cell Physiol Biochem Press GmbH & Co KG
2013-01-01
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| Series: | Cellular Physiology and Biochemistry |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/343343 |
| _version_ | 1828317673723789312 |
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| author | Wu Li Junli He Longxiang Xie Tian Chen Jianping Xie |
| author_facet | Wu Li Junli He Longxiang Xie Tian Chen Jianping Xie |
| author_sort | Wu Li |
| collection | DOAJ |
| description | Iron is essential for nearly all biological events. Siderophores are indispensable for most organisms to obtain iron from iron-limiting milieus. This holds particularly true for pathogens such as the causative agent of tuberculosis – Mycobacterium tuberculosis. The categories of mycobacterial siderophores, their biosynthesis and regulation are summarized here. The siderophore biosynthesis and regulation differences between the pathogenic and non-pathogenic mycobacteria are highlighted from comparative genomic perspective, with an aim to find clues for drug or drug target within siderophore metabolism. |
| first_indexed | 2024-04-13T17:31:43Z |
| format | Article |
| id | doaj.art-b5161d35aea34dd5b0ba4243bae2c4d9 |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-04-13T17:31:43Z |
| publishDate | 2013-01-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-b5161d35aea34dd5b0ba4243bae2c4d92022-12-22T02:37:32ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782013-01-0131111310.1159/000343343343343Comparative Genomic Insights Into the Biosynthesis and Regulation of Mycobacterial SiderophoresWu LiJunli HeLongxiang XieTian ChenJianping XieIron is essential for nearly all biological events. Siderophores are indispensable for most organisms to obtain iron from iron-limiting milieus. This holds particularly true for pathogens such as the causative agent of tuberculosis – Mycobacterium tuberculosis. The categories of mycobacterial siderophores, their biosynthesis and regulation are summarized here. The siderophore biosynthesis and regulation differences between the pathogenic and non-pathogenic mycobacteria are highlighted from comparative genomic perspective, with an aim to find clues for drug or drug target within siderophore metabolism.http://www.karger.com/Article/FullText/343343MycobacteriaSiderophoreBiosynthesisAnti-tuberculosis |
| spellingShingle | Wu Li Junli He Longxiang Xie Tian Chen Jianping Xie Comparative Genomic Insights Into the Biosynthesis and Regulation of Mycobacterial Siderophores Cellular Physiology and Biochemistry Mycobacteria Siderophore Biosynthesis Anti-tuberculosis |
| title | Comparative Genomic Insights Into the Biosynthesis and Regulation of Mycobacterial Siderophores |
| title_full | Comparative Genomic Insights Into the Biosynthesis and Regulation of Mycobacterial Siderophores |
| title_fullStr | Comparative Genomic Insights Into the Biosynthesis and Regulation of Mycobacterial Siderophores |
| title_full_unstemmed | Comparative Genomic Insights Into the Biosynthesis and Regulation of Mycobacterial Siderophores |
| title_short | Comparative Genomic Insights Into the Biosynthesis and Regulation of Mycobacterial Siderophores |
| title_sort | comparative genomic insights into the biosynthesis and regulation of mycobacterial siderophores |
| topic | Mycobacteria Siderophore Biosynthesis Anti-tuberculosis |
| url | http://www.karger.com/Article/FullText/343343 |
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