Antibacterial Effect and Therapy of Chronic Skin Defects Using the Composite Bioscaffold Polycaprolactone/GelitaSpon/Povidone-Iodine in Domestic Dogs
Chronic wounds and the failure of conventional treatment are relatively common in veterinary medicine. Recently, there has been a growing interest in alternative therapeutic approaches and the utilization of biodegradable materials. Their potential application in wound therapy may offer a novel and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/21/4201 |
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| author | Barbora Šišková Martin Kožár Radka Staroňová Ivan Shepa Vanda Hajdučková Patrícia Hudecová Michaela Kaduková Marek Schnitzer |
| author_facet | Barbora Šišková Martin Kožár Radka Staroňová Ivan Shepa Vanda Hajdučková Patrícia Hudecová Michaela Kaduková Marek Schnitzer |
| author_sort | Barbora Šišková |
| collection | DOAJ |
| description | Chronic wounds and the failure of conventional treatment are relatively common in veterinary medicine. Recently, there has been a growing interest in alternative therapeutic approaches and the utilization of biodegradable materials. Their potential application in wound therapy may offer a novel and more suitable option compared to conventional treatment methods. Biodegradable materials can be classified into two main categories: natural, synthetic, and a combination of both, which have the potential to have synergistically enhanced properties. In this study, four domestic dogs with clinical symptoms of chronic wounds were enrolled. These wounds underwent treatment utilizing a novel biodegradable composite material composed of gelatin sponge combined with two electrospun layers of polycaprolactone (PCL) along with polyvinylpyrrolidone (PVP) fibers containing povidone-iodine complex (PVP-I). The initial phase of the study was dedicated to evaluating the antibacterial properties of iodine against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. On average, wound healing in domestic dogs took 22 days from the initial treatment, and iodine concentrations demonstrated a significant antibacterial effect against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. Based on the favorable outcomes observed in wound management, we believe that the utilization of a blend of natural and synthetic biodegradable materials holds promise as an effective wound therapy option. |
| first_indexed | 2024-03-11T11:23:39Z |
| format | Article |
| id | doaj.art-b517f9090dd44524b989af4f10f64353 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T11:23:39Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-b517f9090dd44524b989af4f10f643532023-11-10T15:10:32ZengMDPI AGPolymers2073-43602023-10-011521420110.3390/polym15214201Antibacterial Effect and Therapy of Chronic Skin Defects Using the Composite Bioscaffold Polycaprolactone/GelitaSpon/Povidone-Iodine in Domestic DogsBarbora Šišková0Martin Kožár1Radka Staroňová2Ivan Shepa3Vanda Hajdučková4Patrícia Hudecová5Michaela Kaduková6Marek Schnitzer7Small Animal Clinic, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, SlovakiaSmall Animal Clinic, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, SlovakiaSmall Animal Clinic, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, SlovakiaInstitute of Material Research, Slovak Academy of Sciences, 040 01 Košice, SlovakiaDepartment of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, SlovakiaDepartment of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, SlovakiaDepartment of Parasitology, University of Veterinary Medicine and Pharmacy, Komenského 73, 041 81 Košice, SlovakiaFaculty of Mechanical Engineering, Department of Biomedical Engineering and Measurement, Technical University of Košice, Letná 9, 042 00 Košice, SlovakiaChronic wounds and the failure of conventional treatment are relatively common in veterinary medicine. Recently, there has been a growing interest in alternative therapeutic approaches and the utilization of biodegradable materials. Their potential application in wound therapy may offer a novel and more suitable option compared to conventional treatment methods. Biodegradable materials can be classified into two main categories: natural, synthetic, and a combination of both, which have the potential to have synergistically enhanced properties. In this study, four domestic dogs with clinical symptoms of chronic wounds were enrolled. These wounds underwent treatment utilizing a novel biodegradable composite material composed of gelatin sponge combined with two electrospun layers of polycaprolactone (PCL) along with polyvinylpyrrolidone (PVP) fibers containing povidone-iodine complex (PVP-I). The initial phase of the study was dedicated to evaluating the antibacterial properties of iodine against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. On average, wound healing in domestic dogs took 22 days from the initial treatment, and iodine concentrations demonstrated a significant antibacterial effect against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. Based on the favorable outcomes observed in wound management, we believe that the utilization of a blend of natural and synthetic biodegradable materials holds promise as an effective wound therapy option.https://www.mdpi.com/2073-4360/15/21/4201chronic woundgelatiniodinePCLwound healing |
| spellingShingle | Barbora Šišková Martin Kožár Radka Staroňová Ivan Shepa Vanda Hajdučková Patrícia Hudecová Michaela Kaduková Marek Schnitzer Antibacterial Effect and Therapy of Chronic Skin Defects Using the Composite Bioscaffold Polycaprolactone/GelitaSpon/Povidone-Iodine in Domestic Dogs Polymers chronic wound gelatin iodine PCL wound healing |
| title | Antibacterial Effect and Therapy of Chronic Skin Defects Using the Composite Bioscaffold Polycaprolactone/GelitaSpon/Povidone-Iodine in Domestic Dogs |
| title_full | Antibacterial Effect and Therapy of Chronic Skin Defects Using the Composite Bioscaffold Polycaprolactone/GelitaSpon/Povidone-Iodine in Domestic Dogs |
| title_fullStr | Antibacterial Effect and Therapy of Chronic Skin Defects Using the Composite Bioscaffold Polycaprolactone/GelitaSpon/Povidone-Iodine in Domestic Dogs |
| title_full_unstemmed | Antibacterial Effect and Therapy of Chronic Skin Defects Using the Composite Bioscaffold Polycaprolactone/GelitaSpon/Povidone-Iodine in Domestic Dogs |
| title_short | Antibacterial Effect and Therapy of Chronic Skin Defects Using the Composite Bioscaffold Polycaprolactone/GelitaSpon/Povidone-Iodine in Domestic Dogs |
| title_sort | antibacterial effect and therapy of chronic skin defects using the composite bioscaffold polycaprolactone gelitaspon povidone iodine in domestic dogs |
| topic | chronic wound gelatin iodine PCL wound healing |
| url | https://www.mdpi.com/2073-4360/15/21/4201 |
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