The C-Terminal Acidic Tail Modulates the Anticancer Properties of HMGB1

The C-Terminal Acidic Tail Modulates the Anticancer Properties of HMGB1

Energy metabolism reprogramming was recently listed as a hallmark of cancer. In this process, the switch from pyruvate kinase isoenzyme type M1 to pyruvate kinase isoenzyme type M2 (PKM2) is believed to play a crucial role. Interestingly, the activity of the active form of PKM2 can efficiently be in...

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Bibliographic Details
Main Authors: Chloé Borde, Clémentine Dillard, Aurore L’Honoré, Frédérique Quignon, Marion Hamon, Christophe H. Marchand, Roberta Soares Faccion, Maurício G. S. Costa, Elodie Pramil, Annette K. Larsen, Michèle Sabbah, Stéphane D. Lemaire, Vincent Maréchal, Alexandre E. Escargueil
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
HMGB1
anticancer agent
cell bioenergetics
pyruvate kinase
Online Access:https://www.mdpi.com/1422-0067/23/14/7865

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