Epigallocatechin-3-gallate accelerates relaxation and Ca2+ transient decay and desensitizes myofilaments in healthy and Mybpc3-targeted knock-in cardiomyopathic mice

Epigallocatechin-3-gallate accelerates relaxation and Ca2+ transient decay and desensitizes myofilaments in healthy and Mybpc3-targeted knock-in cardiomyopathic mice

Background. Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac muscle disease with left ventricular hypertrophy, interstitial fibrosis and diastolic dysfunction. Increased myofilament Ca2+ sensitivity could be the underlying cause of diastolic dysfunction. Epigallocatechin-3-gall...

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Bibliographic Details
Main Authors: Felix W. Friedrich, Frederik Flenner, Mahtab Nasib, Thomas Eschenhagen, Lucie Carrier
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Physiology
Subjects:
Relaxation
Hypertrophic Cardiomyopathy
epigallocatechin-3-gallate
Ca2+ transient
Myofilament Ca2+ sensitivity
MYBPC3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00607/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00607/full

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