Epigallocatechin-3-gallate accelerates relaxation and Ca2+ transient decay and desensitizes myofilaments in healthy and Mybpc3-targeted knock-in cardiomyopathic mice

Epigallocatechin-3-gallate accelerates relaxation and Ca2+ transient decay and desensitizes myofilaments in healthy and Mybpc3-targeted knock-in cardiomyopathic mice

Background. Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac muscle disease with left ventricular hypertrophy, interstitial fibrosis and diastolic dysfunction. Increased myofilament Ca2+ sensitivity could be the underlying cause of diastolic dysfunction. Epigallocatechin-3-gall...

Full description

Bibliographic Details
Main Authors:	Felix W. Friedrich, Frederik Flenner, Mahtab Nasib, Thomas Eschenhagen, Lucie Carrier
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-12-01
Series:	Frontiers in Physiology
Subjects:	Relaxation Hypertrophic Cardiomyopathy epigallocatechin-3-gallate Ca2+ transient Myofilament Ca2+ sensitivity MYBPC3
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00607/full

Similar Items

Nebivolol Desensitizes Myofilaments of a Hypertrophic Cardiomyopathy Mouse Model
by: Sabrina Stücker, et al.
Published: (2017-08-01)

Analysis of Contractile Function of Permeabilized Human Hypertrophic Cardiomyopathy Multicellular Heart Tissue
by: Nico Kresin, et al.
Published: (2019-03-01)

Evaluation of MYBPC3 trans-Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes
by: Maksymilian Prondzynski, et al.
Published: (2017-06-01)

Repair of Mybpc3 mRNA by 5′-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy
by: Giulia Mearini, et al.
Published: (2013-01-01)

Methods for assessing cardiac myofilament calcium sensitivity
by: Jarrah M. Dowrick, et al.
Published: (2023-12-01)

Neuroprotective effects of epigallocatechin-3-gallate in an experimental model of Alzheimer’s disease in rat: a histological study
by: Homa Rassouli, et al.
Published: (2009-01-01)

Neuroprotective effects of epigallocatechin-3-gallate in an experimental model of Alzheimer’s disease in rat: a histological study
by: Homa Rassouli, et al.
Published: (2009-01-01)

Novel MYBPC3 Mutations in Indian Population with Cardiomyopathies
by: Rani DS, et al.
Published: (2023-09-01)

Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response
by: Shamim A. K. Chowdhury, et al.
Published: (2020-03-01)

Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy
by: Vasco Sequeira, et al.
Published: (2022-09-01)

An Update on MYBPC3 Gene Mutation in Hypertrophic Cardiomyopathy
by: Bogdan-Sorin Tudurachi, et al.
Published: (2023-06-01)

Untargeted Metabolomics Identifies Potential Hypertrophic Cardiomyopathy Biomarkers in Carriers of <i>MYBPC3</i> Founder Variants
by: Mark Jansen, et al.
Published: (2023-02-01)

Pathogenic Intronic Splice-Affecting Variants in <i>MYBPC3</i> in Three Patients with Hypertrophic Cardiomyopathy
by: Katherine A. Wood, et al.
Published: (2021-06-01)

A human <it>MYBPC3</it> mutation appearing about 10 centuries ago results in a hypertrophic cardiomyopathy with delayed onset, moderate evolution but with a risk of sudden death
by: Teirlinck Carolien H, et al.
Published: (2012-11-01)

Heterogeneous Distribution of Genetic Mutations in Myosin Binding Protein-C Paralogs
by: Darshini A. Desai, et al.
Published: (2022-06-01)

The carbon monoxide prodrug oCOm‐21 increases Ca2+ sensitivity of the cardiac myofilament
by: Fergus M. Payne, et al.
Published: (2024-03-01)

MYBPC3Δ25bp intronic deletion in hypertrophic cardiomyopathy patients and healthy Iranian population
by: Leila Emrahi, et al.
Published: (2021-04-01)

I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model
by: Felix W. Friedrich, et al.
Published: (2015-09-01)

Generation of two iPSC lines from hypertrophic cardiomyopathy patients carrying MYBPC3 and PRKAG2 variants
by: Amit Manhas, et al.
Published: (2022-05-01)

Familial hypertrophic cardiomyopathy: A case with a new mutation in the MYBPC3 gene
by: Olgu Hallioglu Kilinc, et al.
Published: (2017-07-01)

Investigating the role of uncoupling of Troponin I phosphorylation from changes in myofibrillar Ca2+-sensitivity in the pathogenesis of Cardiomyopathy
by: Andrew Easton Messer, et al.
Published: (2014-08-01)

MicroRNA expression profiles in familial hypertrophic cardiomyopathy with myosin-binding protein C3 (MYBPC3) gene mutations
by: Li-rong Lin, et al.
Published: (2022-06-01)

HDAC Inhibition Regulates Cardiac Function by Increasing Myofilament Calcium Sensitivity and Decreasing Diastolic Tension
by: Deborah M. Eaton, et al.
Published: (2022-07-01)

Description of a Cohort with a New Truncating <i>MYBPC3</i> Variant for Hypertrophic Cardiomyopathy in Northern Spain
by: Natalia Fernández Suárez, et al.
Published: (2023-03-01)

A novel Loss-of-function Mutation in MYBPC3 Causes familial hypertrophic cardiomyopathy with extreme intrafamilial phenotypic heterogeneity
by: Peng Y, et al.
Published: (2023-03-01)

A pathogenic nonsense mutation (c.1522C>T) of the MYBPC3 gene is implicated with hypertrophic cardiomyopathy
by: Erru Ni, et al.
Published: (2023-08-01)

Identification of Two Homozygous Variants in <i>MYBPC3</i> and <i>SMYD1</i> Genes Associated with Severe Infantile Cardiomyopathy
by: Marta W. Szulik, et al.
Published: (2023-03-01)

A N-terminal Truncated Intracellular Isoform of Matrix Metalloproteinase-2 Impairs Contractility of Mouse Myocardium
by: David H Lovett, et al.
Published: (2014-09-01)

Long-Term PDE-5A Inhibition Improves Myofilament Function in Left and Right Ventricular Cardiomyocytes through Partially Different Mechanisms in Diabetic Rat Hearts
by: Beáta Bódi, et al.
Published: (2021-11-01)

Myofilament Alterations Associated with Human R14del-Phospholamban Cardiomyopathy
by: Mohit Kumar, et al.
Published: (2023-01-01)

Proteasome inhibition slightly improves cardiac function in mice with hypertrophic cardiomyopathy
by: Saskia eSchlossarek, et al.
Published: (2014-12-01)

The Importance of Epigallocatechin as a Scaffold for Drug Development against Flaviviruses
by: Mônika A. Coronado, et al.
Published: (2023-03-01)

A rare cause of sudden unexpected death syndrome (SUDS) in the first year of life: endomyocardial fibroelastosis (EFE) due to two compound heterozygous MYBPC3 mutations
by: Benno Hartung, et al.
Published: (2021-04-01)

Protein Kinase D Plays a Crucial Role in Maintaining Cardiac Homeostasis by Regulating Post-Translational Modifications of Myofilament Proteins
by: Melissa Herwig, et al.
Published: (2024-02-01)

Epigallocatechin gallate: a review
by: L. Bartosikova, et al.
Published: (2018-10-01)

Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration
by: Hussam E Salhi, et al.
Published: (2016-12-01)

South Asian-Specific MYBPC3Δ25bp Deletion Carriers Display Hypercontraction and Impaired Diastolic Function Under Exercise Stress
by: Sholeh Bazrafshan, et al.
Published: (2021-12-01)

Y6, an Epigallocatechin Gallate Derivative, Reverses ABCG2-Mediated Mitoxantrone Resistance
by: Rui-Qiang Zhao, et al.
Published: (2019-01-01)

Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction of αs1-casein sensitized mice
by: Qianqian Zhang, et al.
Published: (2023-05-01)

ALU transposition induces familial hypertrophic cardiomyopathy
by: Landry Nfonsam, et al.
Published: (2020-01-01)