Ionically Crosslinked Complex Gels Loaded with Oleic Acid-Containing Vesicles for Transdermal Drug Delivery
Skin is an attractive site for drug administration partly because of its easy accessibility and favorable properties (e.g., less invasiveness and high patient compliance) over some other common routes of administration. Despite this, the efficiency in transdermal drug delivery has been largely limit...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/8/725 |
| _version_ | 1797560559527264256 |
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| author | Wing-Fu Lai Ryan Tang Wing-Tak Wong |
| author_facet | Wing-Fu Lai Ryan Tang Wing-Tak Wong |
| author_sort | Wing-Fu Lai |
| collection | DOAJ |
| description | Skin is an attractive site for drug administration partly because of its easy accessibility and favorable properties (e.g., less invasiveness and high patient compliance) over some other common routes of administration. Despite this, the efficiency in transdermal drug delivery has been largely limited by poor skin permeation. To address this problem, this study reports the generation of oleic acid-containing vesicles, which can enhance the drug delivery efficiency while showing good stability and limited skin disruption. Upon being loaded into a complex gel, along with the incorporation of the polymer blending technique, a delivery system exhibiting tunable transdermal flux of 2,3,5,4′-tetrahydroxystilbene 2-O-β-D-glucoside is reported. Taking the good biocompatibility and tunable delivery performance into account, our system warrants further development and optimization for future applications in the treatment of skin diseases. |
| first_indexed | 2024-03-10T18:01:25Z |
| format | Article |
| id | doaj.art-b519c353efb5406ab2afc041c4c7aa2d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T18:01:25Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-b519c353efb5406ab2afc041c4c7aa2d2023-11-20T08:50:03ZengMDPI AGPharmaceutics1999-49232020-08-0112872510.3390/pharmaceutics12080725Ionically Crosslinked Complex Gels Loaded with Oleic Acid-Containing Vesicles for Transdermal Drug DeliveryWing-Fu Lai0Ryan Tang1Wing-Tak Wong2School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, ChinaSchool of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, ChinaDepartment of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong, ChinaSkin is an attractive site for drug administration partly because of its easy accessibility and favorable properties (e.g., less invasiveness and high patient compliance) over some other common routes of administration. Despite this, the efficiency in transdermal drug delivery has been largely limited by poor skin permeation. To address this problem, this study reports the generation of oleic acid-containing vesicles, which can enhance the drug delivery efficiency while showing good stability and limited skin disruption. Upon being loaded into a complex gel, along with the incorporation of the polymer blending technique, a delivery system exhibiting tunable transdermal flux of 2,3,5,4′-tetrahydroxystilbene 2-O-β-D-glucoside is reported. Taking the good biocompatibility and tunable delivery performance into account, our system warrants further development and optimization for future applications in the treatment of skin diseases.https://www.mdpi.com/1999-4923/12/8/725transdermal deliveryvesiclesgeltransdermal fluxskin permeation |
| spellingShingle | Wing-Fu Lai Ryan Tang Wing-Tak Wong Ionically Crosslinked Complex Gels Loaded with Oleic Acid-Containing Vesicles for Transdermal Drug Delivery Pharmaceutics transdermal delivery vesicles gel transdermal flux skin permeation |
| title | Ionically Crosslinked Complex Gels Loaded with Oleic Acid-Containing Vesicles for Transdermal Drug Delivery |
| title_full | Ionically Crosslinked Complex Gels Loaded with Oleic Acid-Containing Vesicles for Transdermal Drug Delivery |
| title_fullStr | Ionically Crosslinked Complex Gels Loaded with Oleic Acid-Containing Vesicles for Transdermal Drug Delivery |
| title_full_unstemmed | Ionically Crosslinked Complex Gels Loaded with Oleic Acid-Containing Vesicles for Transdermal Drug Delivery |
| title_short | Ionically Crosslinked Complex Gels Loaded with Oleic Acid-Containing Vesicles for Transdermal Drug Delivery |
| title_sort | ionically crosslinked complex gels loaded with oleic acid containing vesicles for transdermal drug delivery |
| topic | transdermal delivery vesicles gel transdermal flux skin permeation |
| url | https://www.mdpi.com/1999-4923/12/8/725 |
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