Assessment of bladder filling during prostate cancer radiation therapy with ultrasound and cone-beam CT
Prostate cancer patients undergoing external beam radiation therapy (EBRT) benefit from a full bladder to decrease bowel and bladder toxicity. Ultrasound may offer a proxy metric for evaluation, sparing CBCT dosing. Patients were prospectively enrolled pre-simulation from January 2017 to February 20...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1200270/full |
| _version_ | 1797768432019570688 |
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| author | Kiran Chauhan Daniel K. Ebner Katherine Tzou Karen Ryan Jackson May Tasmeem Kaleem Daniel Miller William Stross Timothy Dean Malouff Robin Landy Gerald Strong Steve Herchko Chris Serago Daniel Michael Trifiletti Robert Clell Miller Steven Buskirk Mark R. Waddle |
| author_facet | Kiran Chauhan Daniel K. Ebner Katherine Tzou Karen Ryan Jackson May Tasmeem Kaleem Daniel Miller William Stross Timothy Dean Malouff Robin Landy Gerald Strong Steve Herchko Chris Serago Daniel Michael Trifiletti Robert Clell Miller Steven Buskirk Mark R. Waddle |
| author_sort | Kiran Chauhan |
| collection | DOAJ |
| description | Prostate cancer patients undergoing external beam radiation therapy (EBRT) benefit from a full bladder to decrease bowel and bladder toxicity. Ultrasound may offer a proxy metric for evaluation, sparing CBCT dosing. Patients were prospectively enrolled pre-simulation from January 2017 to February 2018. Bladder volume was evaluated prior to RT using US daily and CBCT for three daily treatments and then weekly unless otherwise indicated. 29 patients completed median 40 days of RT, resulting in 478 CBCT and 1,099 US bladder volumes. 21 patients were treated to intact glands and 8 to the post-prostatectomy bed. Median patient age was 70 years. Bladder volume on CBCT and US positively correlated (r = 0.85), with average bladder volume for all patients of 162 mL versus 149 mL, respectively. Bladder volume during treatment was consistently lower than the volume at CT simulation (153 mL vs 194 mL, p<0.01) and progressively declined during treatment. Patients older than 70 years presented with lower average bladder volumes than those < 70 years (122 mL vs 208 mL, respectively, p<0.01). Patients with the highest agreement between CBCT and US (<10% variability) had higher average bladder volumes (192 mL vs 120 mL, p=0.01). US was found to be an accurate measure of bladder volume and may be used to monitor daily bladder volumes in patients being treated with radiation for prostate cancer. |
| first_indexed | 2024-03-12T20:53:25Z |
| format | Article |
| id | doaj.art-b51a6116166f4310b23395ce5e251808 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T20:53:25Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b51a6116166f4310b23395ce5e2518082023-07-31T23:12:41ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-07-011310.3389/fonc.2023.12002701200270Assessment of bladder filling during prostate cancer radiation therapy with ultrasound and cone-beam CTKiran Chauhan0Daniel K. Ebner1Katherine Tzou2Karen Ryan3Jackson May4Tasmeem Kaleem5Daniel Miller6William Stross7Timothy Dean Malouff8Robin Landy9Gerald Strong10Steve Herchko11Chris Serago12Daniel Michael Trifiletti13Robert Clell Miller14Steven Buskirk15Mark R. Waddle16Department of Radiation Oncology, Mayo Clinic, Rochester, MN, United StatesDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, United StatesDepartment of Radiation Oncology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL, United StatesCollege of Medicine, Florida State University, Tallahassee, FL, United StatesDepartment of Radiation Oncology, Trihealth System, Cincinnati, OH, United StatesDepartment of Radiation Oncology, Gamma West Cancer Center, Idaho Falls, ID, United StatesDepartment of Radiation Oncology, United States Department of Veterans Affairs, Minneapolis, MN, United StatesDepartment of Radiation Oncology, College of Medicine, University of Oklahoma, Oklahoma City, OK, United StatesCollege of Medicine, Florida State University, Tallahassee, FL, United StatesDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL, United StatesDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL, United StatesDepartment of Therapeutic Radiology, School of Medicine, Yale University, New Haven, CT, United StatesDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL, United States0Department of Radiation Oncology, University of Tennessee Medical Center, Knoxville, TN, United StatesDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL, United StatesDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, United StatesProstate cancer patients undergoing external beam radiation therapy (EBRT) benefit from a full bladder to decrease bowel and bladder toxicity. Ultrasound may offer a proxy metric for evaluation, sparing CBCT dosing. Patients were prospectively enrolled pre-simulation from January 2017 to February 2018. Bladder volume was evaluated prior to RT using US daily and CBCT for three daily treatments and then weekly unless otherwise indicated. 29 patients completed median 40 days of RT, resulting in 478 CBCT and 1,099 US bladder volumes. 21 patients were treated to intact glands and 8 to the post-prostatectomy bed. Median patient age was 70 years. Bladder volume on CBCT and US positively correlated (r = 0.85), with average bladder volume for all patients of 162 mL versus 149 mL, respectively. Bladder volume during treatment was consistently lower than the volume at CT simulation (153 mL vs 194 mL, p<0.01) and progressively declined during treatment. Patients older than 70 years presented with lower average bladder volumes than those < 70 years (122 mL vs 208 mL, respectively, p<0.01). Patients with the highest agreement between CBCT and US (<10% variability) had higher average bladder volumes (192 mL vs 120 mL, p=0.01). US was found to be an accurate measure of bladder volume and may be used to monitor daily bladder volumes in patients being treated with radiation for prostate cancer.https://www.frontiersin.org/articles/10.3389/fonc.2023.1200270/fullbladder fillingIMRTradiotherapyCBCTworkflow |
| spellingShingle | Kiran Chauhan Daniel K. Ebner Katherine Tzou Karen Ryan Jackson May Tasmeem Kaleem Daniel Miller William Stross Timothy Dean Malouff Robin Landy Gerald Strong Steve Herchko Chris Serago Daniel Michael Trifiletti Robert Clell Miller Steven Buskirk Mark R. Waddle Assessment of bladder filling during prostate cancer radiation therapy with ultrasound and cone-beam CT Frontiers in Oncology bladder filling IMRT radiotherapy CBCT workflow |
| title | Assessment of bladder filling during prostate cancer radiation therapy with ultrasound and cone-beam CT |
| title_full | Assessment of bladder filling during prostate cancer radiation therapy with ultrasound and cone-beam CT |
| title_fullStr | Assessment of bladder filling during prostate cancer radiation therapy with ultrasound and cone-beam CT |
| title_full_unstemmed | Assessment of bladder filling during prostate cancer radiation therapy with ultrasound and cone-beam CT |
| title_short | Assessment of bladder filling during prostate cancer radiation therapy with ultrasound and cone-beam CT |
| title_sort | assessment of bladder filling during prostate cancer radiation therapy with ultrasound and cone beam ct |
| topic | bladder filling IMRT radiotherapy CBCT workflow |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1200270/full |
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