Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

T cell expansion and differentiation are critically dependent on the transcription factor c-Myc (Myc). Herein we use quantitative mass-spectrometry to reveal how Myc controls antigen receptor driven cell growth and proteome restructuring in murine T cells. Analysis of copy numbers per cell of &g...

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Bibliografische gegevens
Hoofdauteurs: Julia M Marchingo, Linda V Sinclair, Andrew JM Howden, Doreen A Cantrell
Formaat: Artikel
Taal:English
Gepubliceerd in: eLife Sciences Publications Ltd 2020-02-01
Reeks:eLife
Onderwerpen:
T lymphocyte
T cell activation
proteomics
Myc
amino acid transport
Online toegang:https://elifesciences.org/articles/53725

Internet

https://elifesciences.org/articles/53725

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