New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus <i>Penicillium</i> sp. ZZ1750
Seven novel compounds, namely peniresorcinosides A–E (<b>1</b>–<b>5</b>), penidifarnesylin A (<b>6</b>), and penipyridinone A (<b>7</b>), together with the 11 known ones <b>8</b>–<b>17</b>, were isolated from a culture of the ma...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/19/9/483 |
| _version_ | 1797518465042481152 |
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| author | Kuo Yong Sidra Kaleem Bin Wu Zhizhen Zhang |
| author_facet | Kuo Yong Sidra Kaleem Bin Wu Zhizhen Zhang |
| author_sort | Kuo Yong |
| collection | DOAJ |
| description | Seven novel compounds, namely peniresorcinosides A–E (<b>1</b>–<b>5</b>), penidifarnesylin A (<b>6</b>), and penipyridinone A (<b>7</b>), together with the 11 known ones <b>8</b>–<b>17</b>, were isolated from a culture of the marine-associated fungus <i>Penicillium</i> sp. ZZ1750 in rice medium. The structures of the new compounds were established based on their high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, extensive nuclear magnetic resonance (NMR) spectroscopic analyses, chemical degradation, Mosher’s method, <sup>13</sup>C-NMR calculations, electronic circular dichroism (ECD) calculations, and single crystal X-ray diffraction. Peniresorcinosides A (<b>1</b>) and B (<b>2</b>) are rare glycosylated alkylresorcinols and exhibited potent antiglioma activity, with IC<sub>50</sub> values of 4.0 and 5.6 µM for U87MG cells and 14.1 and 9.8 µM for U251 cells, respectively. |
| first_indexed | 2024-03-10T07:30:16Z |
| format | Article |
| id | doaj.art-b51c10fd18ec4edaac554e48c4ea41c8 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T07:30:16Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-b51c10fd18ec4edaac554e48c4ea41c82023-11-22T13:58:28ZengMDPI AGMarine Drugs1660-33972021-08-0119948310.3390/md19090483New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus <i>Penicillium</i> sp. ZZ1750Kuo Yong0Sidra Kaleem1Bin Wu2Zhizhen Zhang3Ocean College, Zhejiang University, Zhoushan Campus, Zhoushan 316021, ChinaOcean College, Zhejiang University, Zhoushan Campus, Zhoushan 316021, ChinaOcean College, Zhejiang University, Zhoushan Campus, Zhoushan 316021, ChinaOcean College, Zhejiang University, Zhoushan Campus, Zhoushan 316021, ChinaSeven novel compounds, namely peniresorcinosides A–E (<b>1</b>–<b>5</b>), penidifarnesylin A (<b>6</b>), and penipyridinone A (<b>7</b>), together with the 11 known ones <b>8</b>–<b>17</b>, were isolated from a culture of the marine-associated fungus <i>Penicillium</i> sp. ZZ1750 in rice medium. The structures of the new compounds were established based on their high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, extensive nuclear magnetic resonance (NMR) spectroscopic analyses, chemical degradation, Mosher’s method, <sup>13</sup>C-NMR calculations, electronic circular dichroism (ECD) calculations, and single crystal X-ray diffraction. Peniresorcinosides A (<b>1</b>) and B (<b>2</b>) are rare glycosylated alkylresorcinols and exhibited potent antiglioma activity, with IC<sub>50</sub> values of 4.0 and 5.6 µM for U87MG cells and 14.1 and 9.8 µM for U251 cells, respectively.https://www.mdpi.com/1660-3397/19/9/483marine fungus<i>Penicillium</i> sp. ZZ1750peniresorcinosides A–Epenidifarnesylin Apenipyridinone Astructure elucidation |
| spellingShingle | Kuo Yong Sidra Kaleem Bin Wu Zhizhen Zhang New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus <i>Penicillium</i> sp. ZZ1750 Marine Drugs marine fungus <i>Penicillium</i> sp. ZZ1750 peniresorcinosides A–E penidifarnesylin A penipyridinone A structure elucidation |
| title | New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus <i>Penicillium</i> sp. ZZ1750 |
| title_full | New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus <i>Penicillium</i> sp. ZZ1750 |
| title_fullStr | New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus <i>Penicillium</i> sp. ZZ1750 |
| title_full_unstemmed | New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus <i>Penicillium</i> sp. ZZ1750 |
| title_short | New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus <i>Penicillium</i> sp. ZZ1750 |
| title_sort | new antiproliferative compounds against glioma cells from the marine sourced fungus i penicillium i sp zz1750 |
| topic | marine fungus <i>Penicillium</i> sp. ZZ1750 peniresorcinosides A–E penidifarnesylin A penipyridinone A structure elucidation |
| url | https://www.mdpi.com/1660-3397/19/9/483 |
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