Trends and insights in dengue virus research globally: a bibliometric analysis (1995–2023)
Abstract Background Dengue virus (DENV) is the most widespread arbovirus. The World Health Organization (WHO) declared dengue one of the top 10 global health threats in 2019. However, it has been underrepresented in bibliometric analyses. This study employs bibliometric analysis to identify research...
| Главные авторы: | , , , , , , , , |
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| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
BMC
2024-09-01
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| Серии: | Journal of Translational Medicine |
| Предметы: | |
| Online-ссылка: | https://doi.org/10.1186/s12967-024-05561-5 |
| _version_ | 1827124114451595264 |
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| author | Yumeng Liu MengMeng Wang Ning Yu Wenxin Zhao Peng Wang He Zhang Wenchao Sun Ningyi Jin Huijun Lu |
| author_facet | Yumeng Liu MengMeng Wang Ning Yu Wenxin Zhao Peng Wang He Zhang Wenchao Sun Ningyi Jin Huijun Lu |
| author_sort | Yumeng Liu |
| collection | DOAJ |
| description | Abstract Background Dengue virus (DENV) is the most widespread arbovirus. The World Health Organization (WHO) declared dengue one of the top 10 global health threats in 2019. However, it has been underrepresented in bibliometric analyses. This study employs bibliometric analysis to identify research hotspots and trends, offering a comprehensive overview of the current research dynamics in this field. Results We present a report spanning from 1995 to 2023 that provides a unique longitudinal analysis of Dengue virus (DENV) research, revealing significant trends and shifts not extensively covered in previous literature. A total of 10,767 DENV-related documents were considered, with a notable increase in publications, peaking at 747 articles in 2021. Plos Neglected Tropical Diseases has become the leading journal in Dengue virus research, publishing 791 articles in this field—the highest number recorded. Our bibliometric analysis provides a comprehensive mapping of DENV research across multiple dimensions, including vector ecology, virology, and emerging therapies. The study delineates a complex network of immune response genes, including IFNA1, DDX58, IFNB1, STAT1, IRF3, and NFKB1, highlighting significant trends and emerging themes, particularly the impacts of climate change and new outbreaks on disease transmission. Our findings detail the progress and current status of key vaccine candidates, including the licensed Dengvaxia, newer vaccines such as Qdenga and TV003, and updated clinical trials. The study underscores significant advancements in antiviral therapies and vector control strategies for dengue, highlighting innovative drug candidates such as AT-752 and JNJ-1802, and the potential of drug repurposing with agents like Ribavirin, Remdesivir, and Lopinavir. Additionally, it discusses biological control methods, including the introduction of Wolbachia-infected mosquitoes and gene-editing technologies. Conclusion This bibliometric study underscores the critical role of interdisciplinary collaboration in advancing DENV research, identifying key trends and areas needing further exploration, including host-virus dynamics, the development and application of antiviral drugs and vaccines, and the use of artificial intelligence. It advocates for strengthened partnerships across various disciplines to effectively tackle the challenges posed by DENV. |
| first_indexed | 2025-03-20T14:35:40Z |
| format | Article |
| id | doaj.art-b51c5f1a655a4db5867afd1bcd3c47c8 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2025-03-20T14:35:40Z |
| publishDate | 2024-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-b51c5f1a655a4db5867afd1bcd3c47c82024-09-08T11:40:32ZengBMCJournal of Translational Medicine1479-58762024-09-0122111510.1186/s12967-024-05561-5Trends and insights in dengue virus research globally: a bibliometric analysis (1995–2023)Yumeng Liu0MengMeng Wang1Ning Yu2Wenxin Zhao3Peng Wang4He Zhang5Wenchao Sun6Ningyi Jin7Huijun Lu8College of Animal Science and Technology, Guangxi UniversityChangchun Veterinary Research Institute, Chinese Academy of Agricultural SciencesChangchun Veterinary Research Institute, Chinese Academy of Agricultural SciencesChangchun Veterinary Research Institute, Chinese Academy of Agricultural SciencesChangchun Veterinary Research Institute, Chinese Academy of Agricultural SciencesChangchun Veterinary Research Institute, Chinese Academy of Agricultural SciencesWenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou UniversityCollege of Animal Science and Technology, Guangxi UniversityChangchun Veterinary Research Institute, Chinese Academy of Agricultural SciencesAbstract Background Dengue virus (DENV) is the most widespread arbovirus. The World Health Organization (WHO) declared dengue one of the top 10 global health threats in 2019. However, it has been underrepresented in bibliometric analyses. This study employs bibliometric analysis to identify research hotspots and trends, offering a comprehensive overview of the current research dynamics in this field. Results We present a report spanning from 1995 to 2023 that provides a unique longitudinal analysis of Dengue virus (DENV) research, revealing significant trends and shifts not extensively covered in previous literature. A total of 10,767 DENV-related documents were considered, with a notable increase in publications, peaking at 747 articles in 2021. Plos Neglected Tropical Diseases has become the leading journal in Dengue virus research, publishing 791 articles in this field—the highest number recorded. Our bibliometric analysis provides a comprehensive mapping of DENV research across multiple dimensions, including vector ecology, virology, and emerging therapies. The study delineates a complex network of immune response genes, including IFNA1, DDX58, IFNB1, STAT1, IRF3, and NFKB1, highlighting significant trends and emerging themes, particularly the impacts of climate change and new outbreaks on disease transmission. Our findings detail the progress and current status of key vaccine candidates, including the licensed Dengvaxia, newer vaccines such as Qdenga and TV003, and updated clinical trials. The study underscores significant advancements in antiviral therapies and vector control strategies for dengue, highlighting innovative drug candidates such as AT-752 and JNJ-1802, and the potential of drug repurposing with agents like Ribavirin, Remdesivir, and Lopinavir. Additionally, it discusses biological control methods, including the introduction of Wolbachia-infected mosquitoes and gene-editing technologies. Conclusion This bibliometric study underscores the critical role of interdisciplinary collaboration in advancing DENV research, identifying key trends and areas needing further exploration, including host-virus dynamics, the development and application of antiviral drugs and vaccines, and the use of artificial intelligence. It advocates for strengthened partnerships across various disciplines to effectively tackle the challenges posed by DENV.https://doi.org/10.1186/s12967-024-05561-5Dengue Virus (DENV)Global Research TrendsBibliometric AnalysisVaccine DevelopmentAntiviral therapiesVector Control Strategies |
| spellingShingle | Yumeng Liu MengMeng Wang Ning Yu Wenxin Zhao Peng Wang He Zhang Wenchao Sun Ningyi Jin Huijun Lu Trends and insights in dengue virus research globally: a bibliometric analysis (1995–2023) Journal of Translational Medicine Dengue Virus (DENV) Global Research Trends Bibliometric Analysis Vaccine Development Antiviral therapies Vector Control Strategies |
| title | Trends and insights in dengue virus research globally: a bibliometric analysis (1995–2023) |
| title_full | Trends and insights in dengue virus research globally: a bibliometric analysis (1995–2023) |
| title_fullStr | Trends and insights in dengue virus research globally: a bibliometric analysis (1995–2023) |
| title_full_unstemmed | Trends and insights in dengue virus research globally: a bibliometric analysis (1995–2023) |
| title_short | Trends and insights in dengue virus research globally: a bibliometric analysis (1995–2023) |
| title_sort | trends and insights in dengue virus research globally a bibliometric analysis 1995 2023 |
| topic | Dengue Virus (DENV) Global Research Trends Bibliometric Analysis Vaccine Development Antiviral therapies Vector Control Strategies |
| url | https://doi.org/10.1186/s12967-024-05561-5 |
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