Renal control of life-threatening malarial anemia
Summary: Iron recycling prevents the development of anemia under homeostatic conditions. Whether iron recycling was co-opted as a defense strategy to prevent the development of anemia in response to infection is unclear. We find that in severe Plasmodium falciparum malaria, the onset of life-threate...
| Автори: | , , , , , , , , , , , , , , , |
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| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Elsevier
2023-02-01
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| Серія: | Cell Reports |
| Предмети: | |
| Онлайн доступ: | http://www.sciencedirect.com/science/article/pii/S2211124723000682 |
| _version_ | 1828043826853314560 |
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| author | Qian Wu Euclides Sacomboio Lara Valente de Souza Rui Martins Jamil Kitoko Sílvia Cardoso Temitope W. Ademolue Tiago Paixão Jaakko Lehtimäki Ana Figueiredo Caren Norden Pierre-Louis Tharaux Guenter Weiss Fudi Wang Susana Ramos Miguel P. Soares |
| author_facet | Qian Wu Euclides Sacomboio Lara Valente de Souza Rui Martins Jamil Kitoko Sílvia Cardoso Temitope W. Ademolue Tiago Paixão Jaakko Lehtimäki Ana Figueiredo Caren Norden Pierre-Louis Tharaux Guenter Weiss Fudi Wang Susana Ramos Miguel P. Soares |
| author_sort | Qian Wu |
| collection | DOAJ |
| description | Summary: Iron recycling prevents the development of anemia under homeostatic conditions. Whether iron recycling was co-opted as a defense strategy to prevent the development of anemia in response to infection is unclear. We find that in severe Plasmodium falciparum malaria, the onset of life-threatening anemia is associated with acute kidney injury (AKI), irrespective of parasite load. Using a well-established experimental rodent model of malaria anemia, we identify a transcriptional response that endows renal proximal tubule epithelial cells (RPTECs) with the capacity to store and recycle iron during P. chabaudi chabaudi (Pcc) infection. This response encompasses the induction of ferroportin 1/SLC40A1, which exports iron from RPTECs and counteracts AKI while supporting compensatory erythropoiesis and preventing the onset of life-threatening malarial anemia. Iron recycling by myeloid cells is dispensable to this protective response, suggesting that RPTECs provide an iron-recycling salvage pathway that prevents the pathogenesis of life-threatening malarial anemia. |
| first_indexed | 2024-04-10T17:46:47Z |
| format | Article |
| id | doaj.art-b51c6269e0044623b4090c20d9799e29 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-10T17:46:47Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-b51c6269e0044623b4090c20d9799e292023-02-03T04:57:32ZengElsevierCell Reports2211-12472023-02-01422112057Renal control of life-threatening malarial anemiaQian Wu0Euclides Sacomboio1Lara Valente de Souza2Rui Martins3Jamil Kitoko4Sílvia Cardoso5Temitope W. Ademolue6Tiago Paixão7Jaakko Lehtimäki8Ana Figueiredo9Caren Norden10Pierre-Louis Tharaux11Guenter Weiss12Fudi Wang13Susana Ramos14Miguel P. Soares15Instituto Gulbenkian de Ciência, Oeiras, PortugalInstituto de Ciências de Saúde, Luanda, AngolaDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, Innsbruck, Austria; Christian Doppler Laboratory for Iron Metabolism and Anemia Research, Medical University of Innsbruck, Innsbruck, AustriaInstituto Gulbenkian de Ciência, Oeiras, PortugalInstituto Gulbenkian de Ciência, Oeiras, PortugalInstituto Gulbenkian de Ciência, Oeiras, PortugalInstituto Gulbenkian de Ciência, Oeiras, PortugalInstituto Gulbenkian de Ciência, Oeiras, PortugalInstituto Gulbenkian de Ciência, Oeiras, PortugalInstituto Gulbenkian de Ciência, Oeiras, PortugalInstituto Gulbenkian de Ciência, Oeiras, PortugalParis Cardiovascular Center (PARCC), Institut National de la Santé et de la Recherche Médicale (Inserm), Université Paris Cité, Paris, FranceDepartment of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Medical University of Innsbruck, Innsbruck, Austria; Christian Doppler Laboratory for Iron Metabolism and Anemia Research, Medical University of Innsbruck, Innsbruck, AustriaThe First Affiliated Hospital, Institute of Translational Medicine, School of Public Health, Zhejiang University School of Medicine, Hangzhou, ChinaInstituto Gulbenkian de Ciência, Oeiras, Portugal; Corresponding authorInstituto Gulbenkian de Ciência, Oeiras, Portugal; Corresponding authorSummary: Iron recycling prevents the development of anemia under homeostatic conditions. Whether iron recycling was co-opted as a defense strategy to prevent the development of anemia in response to infection is unclear. We find that in severe Plasmodium falciparum malaria, the onset of life-threatening anemia is associated with acute kidney injury (AKI), irrespective of parasite load. Using a well-established experimental rodent model of malaria anemia, we identify a transcriptional response that endows renal proximal tubule epithelial cells (RPTECs) with the capacity to store and recycle iron during P. chabaudi chabaudi (Pcc) infection. This response encompasses the induction of ferroportin 1/SLC40A1, which exports iron from RPTECs and counteracts AKI while supporting compensatory erythropoiesis and preventing the onset of life-threatening malarial anemia. Iron recycling by myeloid cells is dispensable to this protective response, suggesting that RPTECs provide an iron-recycling salvage pathway that prevents the pathogenesis of life-threatening malarial anemia.http://www.sciencedirect.com/science/article/pii/S2211124723000682CP: Immunology |
| spellingShingle | Qian Wu Euclides Sacomboio Lara Valente de Souza Rui Martins Jamil Kitoko Sílvia Cardoso Temitope W. Ademolue Tiago Paixão Jaakko Lehtimäki Ana Figueiredo Caren Norden Pierre-Louis Tharaux Guenter Weiss Fudi Wang Susana Ramos Miguel P. Soares Renal control of life-threatening malarial anemia Cell Reports CP: Immunology |
| title | Renal control of life-threatening malarial anemia |
| title_full | Renal control of life-threatening malarial anemia |
| title_fullStr | Renal control of life-threatening malarial anemia |
| title_full_unstemmed | Renal control of life-threatening malarial anemia |
| title_short | Renal control of life-threatening malarial anemia |
| title_sort | renal control of life threatening malarial anemia |
| topic | CP: Immunology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723000682 |
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