Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats

Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats

Misuse of the psychostimulant methamphetamine (METH) could induce serious hepatotoxicity. Our previous study revealed the effects of luteolin on alleviating METH-induced hepatotoxicity, however, the detailed mechanisms have not been elucidated. In this study, rats were orally pretreated with 100 mg/...

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Bibliographic Details
Main Authors: Kai-Kai Zhang, Hui Wang, Dong Qu, Li-Jian Chen, Li-Bin Wang, Jia-Hao Li, Jia-Li Liu, Ling-Ling Xu, Jamie Still Yoshida, Jing-Tao Xu, Xiao-Li Xie, Dong-Ri Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
methamphetamine
luteolin
hepatotoxicity
protective effect
p53 signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.641917/full

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