Epigenetic Modifications: Therapeutic Potential in Cancer
Epigenetic modifications and alterations in chromatin structure and function contribute to the cumulative changes observed as normal cells undergo malignant transformation. These modifications and enzymes (DNA methyltransferases, histone deacetylases, histone methyltransferases, and demethylases) re...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Instituto de Tecnologia do Paraná (Tecpar)
2015-08-01
|
| Series: | Brazilian Archives of Biology and Technology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400526&lng=en&tlng=en |
| _version_ | 1828777685956952064 |
|---|---|
| author | Manisha Sachan Manpreet Kaur |
| author_facet | Manisha Sachan Manpreet Kaur |
| author_sort | Manisha Sachan |
| collection | DOAJ |
| description | Epigenetic modifications and alterations in chromatin structure and function contribute to the cumulative changes observed as normal cells undergo malignant transformation. These modifications and enzymes (DNA methyltransferases, histone deacetylases, histone methyltransferases, and demethylases) related to them have been deeply studied to develop new drugs, epigenome-targeted therapies and new diagnostic tools. Epigenetic modifiers aim to restore normal epigenetic modification patterns through the inhibition of epigenetic modifier enzymes. Four of them (azacitidine, decitabine, vorinostat and romidepsin) are approved by the U.S. Food and Drug Administration. This article provides an overview about the known functional roles of epigenetic enzymes in cancer development. |
| first_indexed | 2024-12-11T16:27:07Z |
| format | Article |
| id | doaj.art-b51dfdb8c7c34e9ab07e2f9e9a6285be |
| institution | Directory Open Access Journal |
| issn | 1678-4324 |
| language | English |
| last_indexed | 2024-12-11T16:27:07Z |
| publishDate | 2015-08-01 |
| publisher | Instituto de Tecnologia do Paraná (Tecpar) |
| record_format | Article |
| series | Brazilian Archives of Biology and Technology |
| spelling | doaj.art-b51dfdb8c7c34e9ab07e2f9e9a6285be2022-12-22T00:58:42ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1678-43242015-08-0158452653910.1590/S1516-8913201500132S1516-89132015000400526Epigenetic Modifications: Therapeutic Potential in CancerManisha SachanManpreet KaurEpigenetic modifications and alterations in chromatin structure and function contribute to the cumulative changes observed as normal cells undergo malignant transformation. These modifications and enzymes (DNA methyltransferases, histone deacetylases, histone methyltransferases, and demethylases) related to them have been deeply studied to develop new drugs, epigenome-targeted therapies and new diagnostic tools. Epigenetic modifiers aim to restore normal epigenetic modification patterns through the inhibition of epigenetic modifier enzymes. Four of them (azacitidine, decitabine, vorinostat and romidepsin) are approved by the U.S. Food and Drug Administration. This article provides an overview about the known functional roles of epigenetic enzymes in cancer development.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400526&lng=en&tlng=enHDAC inhibitorsCancer epigeneticsHistone modification |
| spellingShingle | Manisha Sachan Manpreet Kaur Epigenetic Modifications: Therapeutic Potential in Cancer Brazilian Archives of Biology and Technology HDAC inhibitors Cancer epigenetics Histone modification |
| title | Epigenetic Modifications: Therapeutic Potential in Cancer |
| title_full | Epigenetic Modifications: Therapeutic Potential in Cancer |
| title_fullStr | Epigenetic Modifications: Therapeutic Potential in Cancer |
| title_full_unstemmed | Epigenetic Modifications: Therapeutic Potential in Cancer |
| title_short | Epigenetic Modifications: Therapeutic Potential in Cancer |
| title_sort | epigenetic modifications therapeutic potential in cancer |
| topic | HDAC inhibitors Cancer epigenetics Histone modification |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400526&lng=en&tlng=en |
| work_keys_str_mv | AT manishasachan epigeneticmodificationstherapeuticpotentialincancer AT manpreetkaur epigeneticmodificationstherapeuticpotentialincancer |