Top-down and bottom-up propagation of disease in the neuronal ceroid lipofuscinoses

Top-down and bottom-up propagation of disease in the neuronal ceroid lipofuscinoses

BackgroundThe Neuronal Ceroid Lipofuscinoses (NCLs) may be considered distinct neurodegenerative disorders with separate underlying molecular causes resulting from monogenetic mutations. An alternative hypothesis is to consider the NCLs as related diseases that share lipofuscin pathobiology as the c...

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Bibliographic Details
Main Authors: John R. Ostergaard, Hemanth R. Nelvagal, Jonathan D. Cooper
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Neurology
Subjects:
neuronal ceroid lipofuscinoses
CLN1
CLN3
connectome
disease propagation
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.1061363/full

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https://www.frontiersin.org/articles/10.3389/fneur.2022.1061363/full

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