Top-down and bottom-up propagation of disease in the neuronal ceroid lipofuscinoses

BackgroundThe Neuronal Ceroid Lipofuscinoses (NCLs) may be considered distinct neurodegenerative disorders with separate underlying molecular causes resulting from monogenetic mutations. An alternative hypothesis is to consider the NCLs as related diseases that share lipofuscin pathobiology as the c...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: John R. Ostergaard, Hemanth R. Nelvagal, Jonathan D. Cooper
Формат: Өгүүллэг
Хэл сонгох:English
Хэвлэсэн: Frontiers Media S.A. 2022-11-01
Цуврал:Frontiers in Neurology
Нөхцлүүд:
Онлайн хандалт:https://www.frontiersin.org/articles/10.3389/fneur.2022.1061363/full