Top-down and bottom-up propagation of disease in the neuronal ceroid lipofuscinoses
BackgroundThe Neuronal Ceroid Lipofuscinoses (NCLs) may be considered distinct neurodegenerative disorders with separate underlying molecular causes resulting from monogenetic mutations. An alternative hypothesis is to consider the NCLs as related diseases that share lipofuscin pathobiology as the c...
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| 格式: | 文件 |
| 语言: | English |
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Frontiers Media S.A.
2022-11-01
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| 丛编: | Frontiers in Neurology |
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| 在线阅读: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1061363/full |