DNA Fingerprint Analysis of Raman Spectra Captures Global Genomic Alterations in Imatinib-Resistant Chronic Myeloid Leukemia: A Potential Single Assay for Screening Imatinib Resistance

DNA Fingerprint Analysis of Raman Spectra Captures Global Genomic Alterations in Imatinib-Resistant Chronic Myeloid Leukemia: A Potential Single Assay for Screening Imatinib Resistance

Monitoring the development of resistance to the tyrosine kinase inhibitor (TKI) imatinib in chronic myeloid leukemia (CML) patients in the initial chronic phase (CP) is crucial for limiting the progression of unresponsive patients to terminal phase of blast crisis (BC). This study for the first time...

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Bibliographic Details
Main Authors: Rahul Mojidra, Arti Hole, Keita Iwasaki, Hemanth Noothalapati, Tatsuyuki Yamamoto, Murali Krishna C, Rukmini Govekar
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
chronic myeloid leukemia
array comparative genomic hybridization
Raman spectroscopy
resistance screening
MCR analysis
Online Access:https://www.mdpi.com/2073-4409/10/10/2506

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