Small protein sequences can induce cellular uptake of complex nanohybrids

In this letter, we report on the ability of functional fusion proteins presenting a lytic gamma peptide, to promote interactions with HeLa cells and delivery of large hybrid nanostructures.

Bibliographic Details
Main Authors: Jan-Philip Merkl, Malak Safi, Christian Schmidtke, Fadi Aldeek, Johannes Ostermann, Tatiana Domitrovic, Sebastian Gärtner, John E. Johnson, Horst Weller, Hedi Mattoussi
Format: Article
Language:English
Published: Beilstein-Institut 2019-12-01
Series:Beilstein Journal of Nanotechnology
Subjects:
Online Access:https://doi.org/10.3762/bjnano.10.238
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author Jan-Philip Merkl
Malak Safi
Christian Schmidtke
Fadi Aldeek
Johannes Ostermann
Tatiana Domitrovic
Sebastian Gärtner
John E. Johnson
Horst Weller
Hedi Mattoussi
author_facet Jan-Philip Merkl
Malak Safi
Christian Schmidtke
Fadi Aldeek
Johannes Ostermann
Tatiana Domitrovic
Sebastian Gärtner
John E. Johnson
Horst Weller
Hedi Mattoussi
author_sort Jan-Philip Merkl
collection DOAJ
description In this letter, we report on the ability of functional fusion proteins presenting a lytic gamma peptide, to promote interactions with HeLa cells and delivery of large hybrid nanostructures.
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spelling doaj.art-b520b9a2a8fa40489d30c7564ad9fb332022-12-22T01:50:03ZengBeilstein-InstitutBeilstein Journal of Nanotechnology2190-42862019-12-011012477248210.3762/bjnano.10.2382190-4286-10-238Small protein sequences can induce cellular uptake of complex nanohybridsJan-Philip Merkl0Malak Safi1Christian Schmidtke2Fadi Aldeek3Johannes Ostermann4Tatiana Domitrovic5Sebastian Gärtner6John E. Johnson7Horst Weller8Hedi Mattoussi9Department of Chemistry and Biochemistry, Florida State University, 95 Chieftan Way, Tallahassee, Florida 32306, United StatesDepartment of Chemistry and Biochemistry, Florida State University, 95 Chieftan Way, Tallahassee, Florida 32306, United StatesInstitute of Physical Chemistry; University of Hamburg, Grindelallee 117, 20146 Hamburg, GermanyDepartment of Chemistry and Biochemistry, Florida State University, 95 Chieftan Way, Tallahassee, Florida 32306, United StatesInstitute of Physical Chemistry; University of Hamburg, Grindelallee 117, 20146 Hamburg, GermanyInstituto de Microbiologia Paulo de Goes, Universidade Federal do Rio de Janeiro, 310. Lab I014, 21941-902, Rio de Janeiro, BrazilInstitute of Physical Chemistry; University of Hamburg, Grindelallee 117, 20146 Hamburg, GermanyThe Scripps Research Institute, Department of Integrative Structural and Computational Biology, MB31, La Jolla, California 92037, United StatesInstitute of Physical Chemistry; University of Hamburg, Grindelallee 117, 20146 Hamburg, GermanyDepartment of Chemistry and Biochemistry, Florida State University, 95 Chieftan Way, Tallahassee, Florida 32306, United StatesIn this letter, we report on the ability of functional fusion proteins presenting a lytic gamma peptide, to promote interactions with HeLa cells and delivery of large hybrid nanostructures.https://doi.org/10.3762/bjnano.10.238bioconjugationcellular uptakenanoparticle hybridspolymer encapsulationself-assembly
spellingShingle Jan-Philip Merkl
Malak Safi
Christian Schmidtke
Fadi Aldeek
Johannes Ostermann
Tatiana Domitrovic
Sebastian Gärtner
John E. Johnson
Horst Weller
Hedi Mattoussi
Small protein sequences can induce cellular uptake of complex nanohybrids
Beilstein Journal of Nanotechnology
bioconjugation
cellular uptake
nanoparticle hybrids
polymer encapsulation
self-assembly
title Small protein sequences can induce cellular uptake of complex nanohybrids
title_full Small protein sequences can induce cellular uptake of complex nanohybrids
title_fullStr Small protein sequences can induce cellular uptake of complex nanohybrids
title_full_unstemmed Small protein sequences can induce cellular uptake of complex nanohybrids
title_short Small protein sequences can induce cellular uptake of complex nanohybrids
title_sort small protein sequences can induce cellular uptake of complex nanohybrids
topic bioconjugation
cellular uptake
nanoparticle hybrids
polymer encapsulation
self-assembly
url https://doi.org/10.3762/bjnano.10.238
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