The prevalence of latent tuberculosis infection in patients with chronic kidney disease: A systematic review and meta-analysis
Objective: To estimate the prevalence of latent tuberculosis infection (LTBI) in chronic kidney disease (CKD) patients. Methods: This study was conducted following the PRISMA guidelines. We identified, 3694 studies from the whole search, and 59 studies were included. Each study's quality was as...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402304389X |
| _version_ | 1827927809558839296 |
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| author | Ayinalem Alemu Zebenay Workneh Bitew Getu Diriba Getachew Seid Shewki Moga Saro Abdella Emebet Gashu Kirubel Eshetu Getachew Tollera Mesay Hailu Dangisso Balako Gumi |
| author_facet | Ayinalem Alemu Zebenay Workneh Bitew Getu Diriba Getachew Seid Shewki Moga Saro Abdella Emebet Gashu Kirubel Eshetu Getachew Tollera Mesay Hailu Dangisso Balako Gumi |
| author_sort | Ayinalem Alemu |
| collection | DOAJ |
| description | Objective: To estimate the prevalence of latent tuberculosis infection (LTBI) in chronic kidney disease (CKD) patients. Methods: This study was conducted following the PRISMA guidelines. We identified, 3694 studies from the whole search, and 59 studies were included. Each study's quality was assessed using JBI checklist. We employed STATA version 17 for statistical analysis. We assessed heterogeneity using I2 heterogeneity test. Publication bias was assessed using funnel plot and Egger's test. We estimated the pooled LTBI prevalence in CKD patients along with 95%CI. Results: The pooled prevalence of LTBI among CKD patients using data collected from 53 studies having 12,772 patients was 30.2% (95%CI; 25.5, 34.8). The pooled prevalence among pre-dialysis, hemodialysis, peritoneal dialysis, and renal transplanted patients was 17.8% (95%CI; 3.3, 32.4), 34.8% (95%CI; 29.1, 40.5), 25% (95%CI; 11, 38), and 16% (95%CI; 7, 25), respectively. The pooled prevalence of LTBI stratified by the laboratory screening methods was 25.3% (95%CI: 20.3–30.3) using TST, 28.0% (95%CI; 23.9–32.0) using QFT, and 32.6%, (95%CI: 23.7–41.5) using T-SPOT. Conclusion: There is high prevalence of LTBI among CKD patients mainly in patients on dialysis. Thus, early diagnosis and treatment of LTBI in CKD patients should be performed to prevent active TB in CKD patients.PROSPERO registration number: CRD42022372441. |
| first_indexed | 2024-03-13T05:58:16Z |
| format | Article |
| id | doaj.art-b5215c5d062542a489081a0dce8e1a1f |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T05:58:16Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-b5215c5d062542a489081a0dce8e1a1f2023-06-13T04:12:39ZengElsevierHeliyon2405-84402023-06-0196e17181The prevalence of latent tuberculosis infection in patients with chronic kidney disease: A systematic review and meta-analysisAyinalem Alemu0Zebenay Workneh Bitew1Getu Diriba2Getachew Seid3Shewki Moga4Saro Abdella5Emebet Gashu6Kirubel Eshetu7Getachew Tollera8Mesay Hailu Dangisso9Balako Gumi10Ethiopian Public Health Institute, Addis Ababa, Ethiopia; Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia; Corresponding author. Ethiopian Public Health Institute, Addis Ababa, Ethiopia.St. Paul's Hospital Millennium Medical College, Addis Ababa, EthiopiaEthiopian Public Health Institute, Addis Ababa, EthiopiaEthiopian Public Health Institute, Addis Ababa, Ethiopia; Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, EthiopiaEthiopian Public Health Institute, Addis Ababa, EthiopiaEthiopian Public Health Institute, Addis Ababa, EthiopiaAddis Ababa Health Bureau, Addis Ababa, EthiopiaUSAID Eliminate TB Project, Management Sciences for Health, Addis Ababa, EthiopiaEthiopian Public Health Institute, Addis Ababa, EthiopiaEthiopian Public Health Institute, Addis Ababa, EthiopiaAklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, EthiopiaObjective: To estimate the prevalence of latent tuberculosis infection (LTBI) in chronic kidney disease (CKD) patients. Methods: This study was conducted following the PRISMA guidelines. We identified, 3694 studies from the whole search, and 59 studies were included. Each study's quality was assessed using JBI checklist. We employed STATA version 17 for statistical analysis. We assessed heterogeneity using I2 heterogeneity test. Publication bias was assessed using funnel plot and Egger's test. We estimated the pooled LTBI prevalence in CKD patients along with 95%CI. Results: The pooled prevalence of LTBI among CKD patients using data collected from 53 studies having 12,772 patients was 30.2% (95%CI; 25.5, 34.8). The pooled prevalence among pre-dialysis, hemodialysis, peritoneal dialysis, and renal transplanted patients was 17.8% (95%CI; 3.3, 32.4), 34.8% (95%CI; 29.1, 40.5), 25% (95%CI; 11, 38), and 16% (95%CI; 7, 25), respectively. The pooled prevalence of LTBI stratified by the laboratory screening methods was 25.3% (95%CI: 20.3–30.3) using TST, 28.0% (95%CI; 23.9–32.0) using QFT, and 32.6%, (95%CI: 23.7–41.5) using T-SPOT. Conclusion: There is high prevalence of LTBI among CKD patients mainly in patients on dialysis. Thus, early diagnosis and treatment of LTBI in CKD patients should be performed to prevent active TB in CKD patients.PROSPERO registration number: CRD42022372441.http://www.sciencedirect.com/science/article/pii/S240584402304389XLatent tuberculosisChronic kidney diseaseDialysisHemodialysisRenal transplantPeritoneal dialysis |
| spellingShingle | Ayinalem Alemu Zebenay Workneh Bitew Getu Diriba Getachew Seid Shewki Moga Saro Abdella Emebet Gashu Kirubel Eshetu Getachew Tollera Mesay Hailu Dangisso Balako Gumi The prevalence of latent tuberculosis infection in patients with chronic kidney disease: A systematic review and meta-analysis Heliyon Latent tuberculosis Chronic kidney disease Dialysis Hemodialysis Renal transplant Peritoneal dialysis |
| title | The prevalence of latent tuberculosis infection in patients with chronic kidney disease: A systematic review and meta-analysis |
| title_full | The prevalence of latent tuberculosis infection in patients with chronic kidney disease: A systematic review and meta-analysis |
| title_fullStr | The prevalence of latent tuberculosis infection in patients with chronic kidney disease: A systematic review and meta-analysis |
| title_full_unstemmed | The prevalence of latent tuberculosis infection in patients with chronic kidney disease: A systematic review and meta-analysis |
| title_short | The prevalence of latent tuberculosis infection in patients with chronic kidney disease: A systematic review and meta-analysis |
| title_sort | prevalence of latent tuberculosis infection in patients with chronic kidney disease a systematic review and meta analysis |
| topic | Latent tuberculosis Chronic kidney disease Dialysis Hemodialysis Renal transplant Peritoneal dialysis |
| url | http://www.sciencedirect.com/science/article/pii/S240584402304389X |
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