Influence of the elevated ambient temperature on immunoglobulin G and immunoglobulin G subclasses in sera of Wistar rats
The aim of our research was to examine changes in the immune system of the rats influenced by the elevated ambient temperature. Male Wistar rats were divided, into 2 groups and housed at 20 ± 2°C (n=64, control group) and 35 ± 1°C (n=74, experimental group), during precise timing of 1, 4, 7, 14, 21,...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2003-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2003/0042-84500306657J.pdf |
| _version_ | 1817995632178102272 |
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| author | Jurhar-Pavlova Maja Petlichkovski Aleksandar Trajkov Dejan Efinska-Mladenovska Olivija Arsov Todor Strezova Ana Dinevska-Kjovkarova Suzana Mitev Slavcho Spiroski Mirko |
| author_facet | Jurhar-Pavlova Maja Petlichkovski Aleksandar Trajkov Dejan Efinska-Mladenovska Olivija Arsov Todor Strezova Ana Dinevska-Kjovkarova Suzana Mitev Slavcho Spiroski Mirko |
| author_sort | Jurhar-Pavlova Maja |
| collection | DOAJ |
| description | The aim of our research was to examine changes in the immune system of the rats influenced by the elevated ambient temperature. Male Wistar rats were divided, into 2 groups and housed at 20 ± 2°C (n=64, control group) and 35 ± 1°C (n=74, experimental group), during precise timing of 1, 4, 7, 14, 21, and 30 days. All the animals were given food and water ad libitum, and were lighted during 12 hours per day. We have measured IgG, IgG1, IgG2a, IgG2b and IgG2c. The obtained results showed significant elevation in the level of IgG after 4 and 7 days (+32%), IgG2a after 7th (+88%), 14th and 21nd day (+110%), IgG2b after 14 days (+60%) at 35 ± 1°C compared with the control group at 20 ± 2°C. IgG1 level was not affected and IgG2c showed significant decrease after 21st day at 35 ± 1°C. In conclusion, during the elevated ambient temperature the immune system is activated as one of the regulation mechanisms in homeostasis and survival of the population. |
| first_indexed | 2024-04-14T02:09:33Z |
| format | Article |
| id | doaj.art-b523543eea3b411889fdfff341474b10 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-04-14T02:09:33Z |
| publishDate | 2003-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-b523543eea3b411889fdfff341474b102022-12-22T02:18:32ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502003-01-0160665766110.2298/VSP0306657JInfluence of the elevated ambient temperature on immunoglobulin G and immunoglobulin G subclasses in sera of Wistar ratsJurhar-Pavlova MajaPetlichkovski AleksandarTrajkov DejanEfinska-Mladenovska OlivijaArsov TodorStrezova AnaDinevska-Kjovkarova SuzanaMitev SlavchoSpiroski MirkoThe aim of our research was to examine changes in the immune system of the rats influenced by the elevated ambient temperature. Male Wistar rats were divided, into 2 groups and housed at 20 ± 2°C (n=64, control group) and 35 ± 1°C (n=74, experimental group), during precise timing of 1, 4, 7, 14, 21, and 30 days. All the animals were given food and water ad libitum, and were lighted during 12 hours per day. We have measured IgG, IgG1, IgG2a, IgG2b and IgG2c. The obtained results showed significant elevation in the level of IgG after 4 and 7 days (+32%), IgG2a after 7th (+88%), 14th and 21nd day (+110%), IgG2b after 14 days (+60%) at 35 ± 1°C compared with the control group at 20 ± 2°C. IgG1 level was not affected and IgG2c showed significant decrease after 21st day at 35 ± 1°C. In conclusion, during the elevated ambient temperature the immune system is activated as one of the regulation mechanisms in homeostasis and survival of the population.http://www.doiserbia.nb.rs/img/doi/0042-8450/2003/0042-84500306657J.pdftemperatureacclimatizationimmune systemimmunoglobulinsimmunoglobulin G |
| spellingShingle | Jurhar-Pavlova Maja Petlichkovski Aleksandar Trajkov Dejan Efinska-Mladenovska Olivija Arsov Todor Strezova Ana Dinevska-Kjovkarova Suzana Mitev Slavcho Spiroski Mirko Influence of the elevated ambient temperature on immunoglobulin G and immunoglobulin G subclasses in sera of Wistar rats Vojnosanitetski Pregled temperature acclimatization immune system immunoglobulins immunoglobulin G |
| title | Influence of the elevated ambient temperature on immunoglobulin G and immunoglobulin G subclasses in sera of Wistar rats |
| title_full | Influence of the elevated ambient temperature on immunoglobulin G and immunoglobulin G subclasses in sera of Wistar rats |
| title_fullStr | Influence of the elevated ambient temperature on immunoglobulin G and immunoglobulin G subclasses in sera of Wistar rats |
| title_full_unstemmed | Influence of the elevated ambient temperature on immunoglobulin G and immunoglobulin G subclasses in sera of Wistar rats |
| title_short | Influence of the elevated ambient temperature on immunoglobulin G and immunoglobulin G subclasses in sera of Wistar rats |
| title_sort | influence of the elevated ambient temperature on immunoglobulin g and immunoglobulin g subclasses in sera of wistar rats |
| topic | temperature acclimatization immune system immunoglobulins immunoglobulin G |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2003/0042-84500306657J.pdf |
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