The association of osteoprotegerin and RANKL with osteoporosis: a systematic review with meta-analysis
Abstract Objectives The OPG/RANKL signal pathway was important regulation mechanism of bone remodeling cycle, but the effect of osteoprotegerin (OPG) and RANKL in osteoporosis was uncertain. We did a systematic review with meta-analysis to assess the association between serum OPG/RANKL and osteoporo...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-11-01
|
| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-023-04179-5 |
| _version_ | 1827764308037074944 |
|---|---|
| author | Guanghao Chi Longshun Qiu Jian Ma Wei Wu Yuxin Zhang |
| author_facet | Guanghao Chi Longshun Qiu Jian Ma Wei Wu Yuxin Zhang |
| author_sort | Guanghao Chi |
| collection | DOAJ |
| description | Abstract Objectives The OPG/RANKL signal pathway was important regulation mechanism of bone remodeling cycle, but the effect of osteoprotegerin (OPG) and RANKL in osteoporosis was uncertain. We did a systematic review with meta-analysis to assess the association between serum OPG/RANKL and osteoporosis. Methods The systematic search, data extraction, critical appraisal, and meta-analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Randomized controlled studies were searched in PubMed, OvidMedline, Embase (1946 to present). Standard mean difference (SMD), and associated credible interval (CI) were calculated using RevMan statistical software to assess the continuous data. Heterogeneity in studies was measured by I 2 values. Subgroup analysis was performed based on different bone turnover. Results A total of 5 randomized controlled studies met the inclusion criteria. Both OPG and RANKL had no significant differences between the osteoporosis and control group, and the statistical heterogeneity was high in meta-analysis. However, RANKL had significant differences between the osteoporosis group with low bone turnover and control group (SMD = − 1.17; 95% CI − 1.77 to 0.57; P value < 0.01) in subanalysis. Furthermore, the OPG/RANKL ratio was significant lower in the osteoporosis group than in the control group (SMD = − 0.29; 95% CI − 0.57 to − 0.02; P value < 0.05), and the statistical heterogeneity was very low (Chi2 = 0.20, P = 0.66, I 2 = 0%). Conclusions Our meta-analysis study supported OPG and RANKL were important modulatory factors of bone formation and resorption in bone turnover, respectively. Although the serum level of both OPG and RANKL were not associated with osteoporosis, but the OPG/RANKL ratio was associated with osteoporosis. In future, standardizing the test method and unit was good to clinical application. |
| first_indexed | 2024-03-11T11:02:28Z |
| format | Article |
| id | doaj.art-b525749f4393473fb46e1423d526070a |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-03-11T11:02:28Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-b525749f4393473fb46e1423d526070a2023-11-12T12:24:24ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2023-11-011811710.1186/s13018-023-04179-5The association of osteoprotegerin and RANKL with osteoporosis: a systematic review with meta-analysisGuanghao Chi0Longshun Qiu1Jian Ma2Wei Wu3Yuxin Zhang4Department of Orthopedics, Hanzhong Central HospitalDepartment of Orthopedics, Hanzhong Central HospitalPing’an Town Health Center Zhenba CountyDepartment of Orthopedics, Hanzhong Central HospitalDepartment of Oral Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineAbstract Objectives The OPG/RANKL signal pathway was important regulation mechanism of bone remodeling cycle, but the effect of osteoprotegerin (OPG) and RANKL in osteoporosis was uncertain. We did a systematic review with meta-analysis to assess the association between serum OPG/RANKL and osteoporosis. Methods The systematic search, data extraction, critical appraisal, and meta-analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Randomized controlled studies were searched in PubMed, OvidMedline, Embase (1946 to present). Standard mean difference (SMD), and associated credible interval (CI) were calculated using RevMan statistical software to assess the continuous data. Heterogeneity in studies was measured by I 2 values. Subgroup analysis was performed based on different bone turnover. Results A total of 5 randomized controlled studies met the inclusion criteria. Both OPG and RANKL had no significant differences between the osteoporosis and control group, and the statistical heterogeneity was high in meta-analysis. However, RANKL had significant differences between the osteoporosis group with low bone turnover and control group (SMD = − 1.17; 95% CI − 1.77 to 0.57; P value < 0.01) in subanalysis. Furthermore, the OPG/RANKL ratio was significant lower in the osteoporosis group than in the control group (SMD = − 0.29; 95% CI − 0.57 to − 0.02; P value < 0.05), and the statistical heterogeneity was very low (Chi2 = 0.20, P = 0.66, I 2 = 0%). Conclusions Our meta-analysis study supported OPG and RANKL were important modulatory factors of bone formation and resorption in bone turnover, respectively. Although the serum level of both OPG and RANKL were not associated with osteoporosis, but the OPG/RANKL ratio was associated with osteoporosis. In future, standardizing the test method and unit was good to clinical application.https://doi.org/10.1186/s13018-023-04179-5OsteoporosisBone turnoverOsteoprotegerinRANKLMeta-analysis |
| spellingShingle | Guanghao Chi Longshun Qiu Jian Ma Wei Wu Yuxin Zhang The association of osteoprotegerin and RANKL with osteoporosis: a systematic review with meta-analysis Journal of Orthopaedic Surgery and Research Osteoporosis Bone turnover Osteoprotegerin RANKL Meta-analysis |
| title | The association of osteoprotegerin and RANKL with osteoporosis: a systematic review with meta-analysis |
| title_full | The association of osteoprotegerin and RANKL with osteoporosis: a systematic review with meta-analysis |
| title_fullStr | The association of osteoprotegerin and RANKL with osteoporosis: a systematic review with meta-analysis |
| title_full_unstemmed | The association of osteoprotegerin and RANKL with osteoporosis: a systematic review with meta-analysis |
| title_short | The association of osteoprotegerin and RANKL with osteoporosis: a systematic review with meta-analysis |
| title_sort | association of osteoprotegerin and rankl with osteoporosis a systematic review with meta analysis |
| topic | Osteoporosis Bone turnover Osteoprotegerin RANKL Meta-analysis |
| url | https://doi.org/10.1186/s13018-023-04179-5 |
| work_keys_str_mv | AT guanghaochi theassociationofosteoprotegerinandranklwithosteoporosisasystematicreviewwithmetaanalysis AT longshunqiu theassociationofosteoprotegerinandranklwithosteoporosisasystematicreviewwithmetaanalysis AT jianma theassociationofosteoprotegerinandranklwithosteoporosisasystematicreviewwithmetaanalysis AT weiwu theassociationofosteoprotegerinandranklwithosteoporosisasystematicreviewwithmetaanalysis AT yuxinzhang theassociationofosteoprotegerinandranklwithosteoporosisasystematicreviewwithmetaanalysis AT guanghaochi associationofosteoprotegerinandranklwithosteoporosisasystematicreviewwithmetaanalysis AT longshunqiu associationofosteoprotegerinandranklwithosteoporosisasystematicreviewwithmetaanalysis AT jianma associationofosteoprotegerinandranklwithosteoporosisasystematicreviewwithmetaanalysis AT weiwu associationofosteoprotegerinandranklwithosteoporosisasystematicreviewwithmetaanalysis AT yuxinzhang associationofosteoprotegerinandranklwithosteoporosisasystematicreviewwithmetaanalysis |