Non-canonical Interaction Between O-Linked N-Acetylglucosamine Transferase and miR-146a-5p Aggravates High Glucose-Induced Endothelial Inflammation

Non-canonical Interaction Between O-Linked N-Acetylglucosamine Transferase and miR-146a-5p Aggravates High Glucose-Induced Endothelial Inflammation

Background and Aims: Increased O-GlcNAc transferase (OGT)–induced O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification is linked with diabetic complications. MicroRNA-146a-5p (miR-146a-5p) is a negative inflammatory regulator and is downregulated in diabetes. Here, we investigated...

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Bibliographic Details
Main Authors: Wan-Yu Lo, Shou-Jie Wang, Huang-Joe Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Physiology
Subjects:
diabetes
high glucose
O-Linked N-acetylglucosamine transferase (OGT)
protein O-GlcNAcylation
microRNA-146a-5p
endothelial inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.01091/full

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