Phosphorylation of AGO2 by TBK1 Promotes the Formation of Oncogenic miRISC in NSCLC

Phosphorylation of AGO2 by TBK1 Promotes the Formation of Oncogenic miRISC in NSCLC

Abstract Non‐small‐cell lung cancer (NSCLC) is a highly lethal tumor that often develops resistance to targeted therapy. It is shown that Tank‐binding kinase 1 (TBK1) phosphorylates AGO2 at S417 (pS417‐AGO2), which promotes NSCLC progression by increasing the formation of microRNA‐induced silencing...

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Bibliographic Details
Main Authors: Xian Zhao, Yingting Cao, Runhui Lu, Zihan Zhou, Caihu Huang, Lian Li, Jiayi Huang, Ran Chen, Yanli Wang, Jian Huang, Jinke Cheng, Junke Zheng, Yujie Fu, Jianxiu Yu
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Advanced Science
Subjects:
AGO2
Gefitinib
miRISC
non‐small‐cell lung cancer (NSCLC)
TBK1
Online Access:https://doi.org/10.1002/advs.202305541

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