335 Ischemic conditioning improves dynamic balance during treadmill walking in chronic stroke survivors
OBJECTIVES/GOALS: Evaluate the use of IC to improve stroke survivors’ capacity for reactive stepping and adapt their gait cycles in response to a difficult walking environment. We hypothesize that IC will improve stroke survivors’ protective stepping response via improvements in muscle activation an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2024-04-01
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| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866124002991/type/journal_article |
| _version_ | 1797226904862851072 |
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| author | Stephanie Raab Julia Athans Zachary Kroll Emilie Klevenow Matthew Durand Brian Schmit Allison Hyngstrom |
| author_facet | Stephanie Raab Julia Athans Zachary Kroll Emilie Klevenow Matthew Durand Brian Schmit Allison Hyngstrom |
| author_sort | Stephanie Raab |
| collection | DOAJ |
| description | OBJECTIVES/GOALS: Evaluate the use of IC to improve stroke survivors’ capacity for reactive stepping and adapt their gait cycles in response to a difficult walking environment. We hypothesize that IC will improve stroke survivors’ protective stepping response via improvements in muscle activation and motor learning METHODS/STUDY POPULATION: Stroke survivors have an impaired capacity for protective stepping. Decreased paretic muscle activation results in increased reaction time and reduced force generation. Ischemic conditioning (IC) is a vascular stimulus which improves motor performance in chronic stroke. It is performed by delivering transient, intermittent bouts of ischemia to a limb. It has been demonstrated that IC increases muscle activation post-stroke. 9 chronic stroke survivors completed 3 testing sessions and 7 intervention sessions. Participants walked on an instrumented treadmill and were perturbed unilaterally every step at the waist via a cable pulley system. Kinetic and kinematic data were collected. Step width was measured as the difference in position of the heel markers at the instant of heel strike in the frontal plane. RESULTS/ANTICIPATED RESULTS: After one and seven sessions of IC, controls did not alter their responses from baseline testing, but stroke survivors increased their step width by an average of 15% and 23% respectively. DISCUSSION/SIGNIFICANCE: Ischemic conditioning may be a useful intervention to improve stroke survivors’ ability to adapt their paretic foot placement in response to lateral perturbations during gait. Interventions which optimize muscle activation and neural adaptation could significantly improve balance post-stroke. |
| first_indexed | 2024-04-24T14:32:19Z |
| format | Article |
| id | doaj.art-b52c8eb5bd4b4126bb8779bf67051365 |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-24T14:32:19Z |
| publishDate | 2024-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-b52c8eb5bd4b4126bb8779bf670513652024-04-03T02:00:25ZengCambridge University PressJournal of Clinical and Translational Science2059-86612024-04-01810110210.1017/cts.2024.299335 Ischemic conditioning improves dynamic balance during treadmill walking in chronic stroke survivorsStephanie Raab0Julia Athans1Zachary Kroll2Emilie Klevenow3Matthew Durand4Brian Schmit5Allison Hyngstrom6Marquette UniversityMarquette UniversityMarquette University and Medical College of WisconsinMarquette UniversityMedical College of WisconsinMarquette University and Medical College of WisconsinMarquette UniversityOBJECTIVES/GOALS: Evaluate the use of IC to improve stroke survivors’ capacity for reactive stepping and adapt their gait cycles in response to a difficult walking environment. We hypothesize that IC will improve stroke survivors’ protective stepping response via improvements in muscle activation and motor learning METHODS/STUDY POPULATION: Stroke survivors have an impaired capacity for protective stepping. Decreased paretic muscle activation results in increased reaction time and reduced force generation. Ischemic conditioning (IC) is a vascular stimulus which improves motor performance in chronic stroke. It is performed by delivering transient, intermittent bouts of ischemia to a limb. It has been demonstrated that IC increases muscle activation post-stroke. 9 chronic stroke survivors completed 3 testing sessions and 7 intervention sessions. Participants walked on an instrumented treadmill and were perturbed unilaterally every step at the waist via a cable pulley system. Kinetic and kinematic data were collected. Step width was measured as the difference in position of the heel markers at the instant of heel strike in the frontal plane. RESULTS/ANTICIPATED RESULTS: After one and seven sessions of IC, controls did not alter their responses from baseline testing, but stroke survivors increased their step width by an average of 15% and 23% respectively. DISCUSSION/SIGNIFICANCE: Ischemic conditioning may be a useful intervention to improve stroke survivors’ ability to adapt their paretic foot placement in response to lateral perturbations during gait. Interventions which optimize muscle activation and neural adaptation could significantly improve balance post-stroke.https://www.cambridge.org/core/product/identifier/S2059866124002991/type/journal_article |
| spellingShingle | Stephanie Raab Julia Athans Zachary Kroll Emilie Klevenow Matthew Durand Brian Schmit Allison Hyngstrom 335 Ischemic conditioning improves dynamic balance during treadmill walking in chronic stroke survivors Journal of Clinical and Translational Science |
| title | 335 Ischemic conditioning improves dynamic balance during treadmill walking in chronic stroke survivors |
| title_full | 335 Ischemic conditioning improves dynamic balance during treadmill walking in chronic stroke survivors |
| title_fullStr | 335 Ischemic conditioning improves dynamic balance during treadmill walking in chronic stroke survivors |
| title_full_unstemmed | 335 Ischemic conditioning improves dynamic balance during treadmill walking in chronic stroke survivors |
| title_short | 335 Ischemic conditioning improves dynamic balance during treadmill walking in chronic stroke survivors |
| title_sort | 335 ischemic conditioning improves dynamic balance during treadmill walking in chronic stroke survivors |
| url | https://www.cambridge.org/core/product/identifier/S2059866124002991/type/journal_article |
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