Segmented solenoid RF coils for MRI of ex vivo brain samples at ultra-high field preclinical and clinical scanners
Magnetic resonance imaging (MRI) is a well-known and widespread imaging modality for neuroscience studies and the clinical diagnoses of neurological disorders, mainly due to its capability to visualize brain microstructures and quantify various metabolites. Additionally, its noninvasive nature makes...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Journal of Magnetic Resonance Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666441023000110 |
| _version_ | 1797394774698754048 |
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| author | Daniel Papoti Diego Szczupak Luiz G.C. Santos Khallil T. Chaim Maria C.G. Otaduy David J. Schaeffer Edson L.G. Vidoto Alberto Tannús Afonso C. Silva |
| author_facet | Daniel Papoti Diego Szczupak Luiz G.C. Santos Khallil T. Chaim Maria C.G. Otaduy David J. Schaeffer Edson L.G. Vidoto Alberto Tannús Afonso C. Silva |
| author_sort | Daniel Papoti |
| collection | DOAJ |
| description | Magnetic resonance imaging (MRI) is a well-known and widespread imaging modality for neuroscience studies and the clinical diagnoses of neurological disorders, mainly due to its capability to visualize brain microstructures and quantify various metabolites. Additionally, its noninvasive nature makes possible the correlation of high-resolution MRI from ex vivo brain samples with histology, supporting the study of neurodegenerative disorders such as Alzheimer's or Parkinson's disease. However, the quality and resolution of ex vivo MRI highly depend on the availability of specialized radiofrequency coils with maximized filling factors for the different sizes and shapes of the samples to be studied. For instance, small, dedicated radiofrequency (RF) coils are not always commercially available in ultrahigh field whole-body MRI scanners. Even for ultrahigh field preclinical scanners, specific RF coils for ex vivo MRI are expensive and not always available. Here, we describe the design and construction of two RF coils based on the solenoid geometry for ex vivo MRI of human brain tissues in a 7T whole-body scanner and for ex vivo MRI of marmoset brain samples in a 9.4T preclinical scanner. We designed the 7T solenoid RF coil to maximize the filling factor of human brain samples conditioned on cassettes for histology, while the 9.4T solenoid was constructed to accommodate marmoset brain samples conditioned in 50 ml centrifuge tubes. Both solenoid designs operate in transceiver mode. The measured B1+ maps show a high level of homogeneity in the imaging volume of interest, with a high signal-to-noise ratio over the imaging volume. High-resolution (80 µm in plane, 500 µm slice thickness) images of human brain samples were acquired with the 7T solenoid, while marmoset brain samples were acquired with an isotropic resolution of 60 µm using the 9.4T solenoid coil. |
| first_indexed | 2024-03-09T00:24:33Z |
| format | Article |
| id | doaj.art-b52ca513c63044aca2089a3fd14a8c2d |
| institution | Directory Open Access Journal |
| issn | 2666-4410 |
| language | English |
| last_indexed | 2024-03-09T00:24:33Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Magnetic Resonance Open |
| spelling | doaj.art-b52ca513c63044aca2089a3fd14a8c2d2023-12-12T04:36:31ZengElsevierJournal of Magnetic Resonance Open2666-44102023-12-0116100103Segmented solenoid RF coils for MRI of ex vivo brain samples at ultra-high field preclinical and clinical scannersDaniel Papoti0Diego Szczupak1Luiz G.C. Santos2Khallil T. Chaim3Maria C.G. Otaduy4David J. Schaeffer5Edson L.G. Vidoto6Alberto Tannús7Afonso C. Silva8Department of Neurobiology, University of Pittsburgh, 3501 Fifth Avenue, 3058 Biomedical Science Tower 3, Pittsburgh, PA, 15261, United States of America; Universidade Federal do ABC, Rua Arcturus, 03 – Jardim antares, São Bernardo do Campo, São Paulo, 09606-070, Brazil; Corresponding author.Department of Neurobiology, University of Pittsburgh, 3501 Fifth Avenue, 3058 Biomedical Science Tower 3, Pittsburgh, PA, 15261, United States of AmericaUniversidade Federal do ABC, Rua Arcturus, 03 – Jardim antares, São Bernardo do Campo, São Paulo, 09606-070, BrazilLIM44 - Instituto e Departamento de Radiologia, Faculdade de Medicina da Universidade de São Paulo, Travessa da R. Ovídio Pires de Campos, 75, São Paulo, São Paulo, 05403-010, BrazilLIM44 - Instituto e Departamento de Radiologia, Faculdade de Medicina da Universidade de São Paulo, Travessa da R. Ovídio Pires de Campos, 75, São Paulo, São Paulo, 05403-010, BrazilDepartment of Neurobiology, University of Pittsburgh, 3501 Fifth Avenue, 3058 Biomedical Science Tower 3, Pittsburgh, PA, 15261, United States of AmericaCentro de Imagens e Espectroscopia por Ressonância Magnética - Instituto de Física de São Carlos, Universidade de São Paulo, Avenida Trabalhador São Carlense, 400, São Carlos, São Paulo, 13566-590, BrazilCentro de Imagens e Espectroscopia por Ressonância Magnética - Instituto de Física de São Carlos, Universidade de São Paulo, Avenida Trabalhador São Carlense, 400, São Carlos, São Paulo, 13566-590, BrazilDepartment of Neurobiology, University of Pittsburgh, 3501 Fifth Avenue, 3058 Biomedical Science Tower 3, Pittsburgh, PA, 15261, United States of AmericaMagnetic resonance imaging (MRI) is a well-known and widespread imaging modality for neuroscience studies and the clinical diagnoses of neurological disorders, mainly due to its capability to visualize brain microstructures and quantify various metabolites. Additionally, its noninvasive nature makes possible the correlation of high-resolution MRI from ex vivo brain samples with histology, supporting the study of neurodegenerative disorders such as Alzheimer's or Parkinson's disease. However, the quality and resolution of ex vivo MRI highly depend on the availability of specialized radiofrequency coils with maximized filling factors for the different sizes and shapes of the samples to be studied. For instance, small, dedicated radiofrequency (RF) coils are not always commercially available in ultrahigh field whole-body MRI scanners. Even for ultrahigh field preclinical scanners, specific RF coils for ex vivo MRI are expensive and not always available. Here, we describe the design and construction of two RF coils based on the solenoid geometry for ex vivo MRI of human brain tissues in a 7T whole-body scanner and for ex vivo MRI of marmoset brain samples in a 9.4T preclinical scanner. We designed the 7T solenoid RF coil to maximize the filling factor of human brain samples conditioned on cassettes for histology, while the 9.4T solenoid was constructed to accommodate marmoset brain samples conditioned in 50 ml centrifuge tubes. Both solenoid designs operate in transceiver mode. The measured B1+ maps show a high level of homogeneity in the imaging volume of interest, with a high signal-to-noise ratio over the imaging volume. High-resolution (80 µm in plane, 500 µm slice thickness) images of human brain samples were acquired with the 7T solenoid, while marmoset brain samples were acquired with an isotropic resolution of 60 µm using the 9.4T solenoid coil.http://www.sciencedirect.com/science/article/pii/S2666441023000110RF coilsMagnetic resonance imagingEx vivo MRISolenoid coils |
| spellingShingle | Daniel Papoti Diego Szczupak Luiz G.C. Santos Khallil T. Chaim Maria C.G. Otaduy David J. Schaeffer Edson L.G. Vidoto Alberto Tannús Afonso C. Silva Segmented solenoid RF coils for MRI of ex vivo brain samples at ultra-high field preclinical and clinical scanners Journal of Magnetic Resonance Open RF coils Magnetic resonance imaging Ex vivo MRI Solenoid coils |
| title | Segmented solenoid RF coils for MRI of ex vivo brain samples at ultra-high field preclinical and clinical scanners |
| title_full | Segmented solenoid RF coils for MRI of ex vivo brain samples at ultra-high field preclinical and clinical scanners |
| title_fullStr | Segmented solenoid RF coils for MRI of ex vivo brain samples at ultra-high field preclinical and clinical scanners |
| title_full_unstemmed | Segmented solenoid RF coils for MRI of ex vivo brain samples at ultra-high field preclinical and clinical scanners |
| title_short | Segmented solenoid RF coils for MRI of ex vivo brain samples at ultra-high field preclinical and clinical scanners |
| title_sort | segmented solenoid rf coils for mri of ex vivo brain samples at ultra high field preclinical and clinical scanners |
| topic | RF coils Magnetic resonance imaging Ex vivo MRI Solenoid coils |
| url | http://www.sciencedirect.com/science/article/pii/S2666441023000110 |
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