Identification of neprilysin as a potential target of arteannuin using computational drug repositioning

Identification of neprilysin as a potential target of arteannuin using computational drug repositioning

ABSTRACT The discovery of arteannuin (qinghaosu) in the 20th Century was a major advance for medicine. Besides functioning as a malaria therapy, arteannuin is a pharmacological agent in a range of other diseases, but its mechanism of action remains obscure. In this study, the reverse docking server...

Full description

Bibliographic Details
Main Authors:	Xuan-Yi Ye, Qing-Zhi Ling, Shao-Jun Chen
Format:	Article
Language:	English
Published:	Universidade de São Paulo 2017-06-01
Series:	Brazilian Journal of Pharmaceutical Sciences
Subjects:	Arteannuin/chemical-protein interactome Computational drug repositioning Neprilysin/identification Reverse docking
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200614&lng=en&tlng=en

Similar Items

Development of Arteannuin B Sustained-Release Microspheres for Anti-Tumor Therapy by Integrated Experimental and Molecular Modeling Approaches
by: Yanqing Wang, et al.
Published: (2021-08-01)

Neprilysin Inhibitors and Bradykinin
by: Duncan J. Campbell, et al.
Published: (2018-09-01)

β-(4-fluorobenzyl) Arteannuin B induced interaction of ATF-4 and C/EBPβ mediates the transition of breast cancer cells from autophagy to senescence
by: Khalid Bashir Mir, et al.
Published: (2022-11-01)

Plasma Neprilysin Displays No Relevant Association With Neurohumoral Activation in Chronic HFrEF
by: Suriya Prausmüller, et al.
Published: (2020-06-01)

Soluble neprilysin and survival in critically ill patients
by: Max Lenz, et al.
Published: (2022-04-01)

Four New Compounds Obtained from Cultured Cells of Artemisia annua
by: Jianhua Zhu, et al.
Published: (2017-12-01)

Differential Interactome Based Drug Repositioning Unraveled Abacavir, Exemestane, Nortriptyline Hydrochloride, and Tolcapone as Potential Therapeutics for Colorectal Cancers
by: Hande Beklen, et al.
Published: (2021-09-01)

The immuneregulator role of neprilysin (NEP) in invertebrates
by: E Ottaviani, et al.
Published: (2012-11-01)

The immuneregulator role of neprilysin (NEP) in invertebrates
by: E Ottaviani, et al.
Published: (2012-11-01)

Impact of the angiotensin receptor‐neprilysin inhibitor in clinical diabetes management: Potential benefits and pitfalls
by: Tomoko Kato, et al.
Published: (2023-09-01)

Serum Neprilysin and Recurrent Admissions in Patients With Heart Failure
by: Julio Núñez, et al.
Published: (2017-08-01)

Amyloid beta and Alzheimer’s Disease: The role of neprilysin-2 in amyloid-beta clearance
by: Robert eMarr, et al.
Published: (2014-08-01)

Determination of Artemisinin Content in Artemisia annua L .
by: Jambalsuren Bayarmaa, et al.
Published: (2011-12-01)

A computational multi-targeting approach for drug repositioning for psoriasis treatment
by: Akachukwu Ibezim, et al.
Published: (2021-07-01)

Arteannuin-B and (3-Chlorophenyl)-2-Spiroisoxazoline Derivative Exhibit Anti-Inflammatory Effects in LPS-Activated RAW 264.7 Macrophages and BALB/c Mice-Induced Proinflammatory Responses via Downregulation of NF-κB/P38 MAPK Signaling
by: Gifty Sawhney, et al.
Published: (2022-11-01)

Relevance of Neutrophil Neprilysin in Heart Failure
by: Suriya Prausmüller, et al.
Published: (2021-10-01)

Breakthrough in Heart Failure therapy: LCZ696 combining ACE-Neprilysin inhibition
by: Sandeep Lahiry
Published: (2017-01-01)

Soluble Neprilysin in the General Population: Clinical Determinants and Its Relationship to Cardiovascular Disease
by: Yogesh N. V. Reddy, et al.
Published: (2019-08-01)

Neprilysin Inhibition in the Prevention of Anthracycline-Induced Cardiotoxicity
by: Aleksandra M. Sobiborowicz-Sadowska, et al.
Published: (2023-01-01)

Effects of neprilysin-renin inhibition in comparison with neprilysin-angiotensin inhibition on the neurohumoral changes in rats with heart failure
by: Kawa Dizaye, et al.
Published: (2019-05-01)

Snail protein inhibition by drug repositioning for recurrent breast cancer: an in-silico study
by: M. Benguella-Benmansour, et al.
Published: (2023-05-01)

Roles of Natriuretic Peptides and the Significance of Neprilysin in Cardiovascular Diseases
by: Hitoshi Nakagawa, et al.
Published: (2022-07-01)

Adipolin, Chemerin, Neprilysin and Metabolic Disorders Associated with Obesity
by: Marcelina Sperling, et al.
Published: (2023-07-01)

Angiotensin receptor-neprilysin inhibitors and cardiac remodeling
by: A.S. Ryazanov, et al.
Published: (2023-04-01)

Repositioning FDA Drugs as Potential Cruzain Inhibitors from Trypanosoma cruzi: Virtual Screening, In Vitro and In Vivo Studies
by: Isidro Palos, et al.
Published: (2017-06-01)

Angiotensin receptor-neprilysin inhibitor for the treatment of heart failure: a review of recent evidence
by: Hong-Mi Choi, et al.
Published: (2020-05-01)

Discovery of drug targets and therapeutic agents based on drug repositioning to treat lung adenocarcinoma
by: Occam Kelly Graves, et al.
Published: (2023-05-01)

Angiotensin receptor neprilysin inhibitor as a novel antihypertensive drug: Evidence from Asia and around the globe
by: Donna S.‐H. Lin, et al.
Published: (2021-03-01)

Clinical efficacy of angiotensin receptor-neprilysin inhibitor in de novo heart failure with reduced ejection fraction
by: Su Yeong Park, et al.
Published: (2023-09-01)

Angiotensin Receptor-Neprilysin Inhibitor (ARNI) and Cardiac Arrhythmias
by: Henry Sutanto, et al.
Published: (2021-08-01)

B-Type Natriuretic Peptide (BNP) Revisited—Is BNP Still a Biomarker for Heart Failure in the Angiotensin Receptor/Neprilysin Inhibitor Era?
by: Toshio Nishikimi, et al.
Published: (2022-07-01)

Effects of the Angiotensin‐Receptor Neprilysin Inhibitor on Cardiac Reverse Remodeling: Meta‐Analysis
by: Yiwen Wang, et al.
Published: (2019-07-01)

Enzyme Replacement Therapy for FABRY Disease: Possible Strategies to Improve Its Efficacy
by: Ilaria Iacobucci, et al.
Published: (2023-02-01)

Computational Drug Repositioning for Chagas Disease Using Protein-Ligand Interaction Profiling
by: Alfredo Juárez-Saldivar, et al.
Published: (2020-06-01)

Recent computational drug repositioning strategies against SARS-CoV-2
by: Lu Lu, et al.
Published: (2022-01-01)

Development of Pigmentation-Regulating Agents by Drug Repositioning
by: Seo-Mi-Gon Jeong, et al.
Published: (2021-04-01)

A Proteotranscriptomic-Based Computational Drug-Repositioning Method for Alzheimer’s Disease
by: Soo Youn Lee, et al.
Published: (2020-01-01)

Drug repositioning or target repositioning: A structural perspective of drug-target-indication relationship for available repurposed drugs
by: Daniele Parisi, et al.
Published: (2020-01-01)

Circulating Neprilysin Level Predicts the Risk of Cardiovascular Events in Hemodialysis Patients
by: Hyeon Seok Hwang, et al.
Published: (2021-06-01)

The Association between Neprilysin gene polymorphisms and Alzheimer’s disease in Tibetan population
by: Siwei Chen, et al.
Published: (2021-03-01)