Synthesis and Pharmacological Evaluation of Novel 2,3,4,5-tetrahydro[1,3]diazepino[1,2-<i>a</i>]benzimidazole Derivatives as Promising Anxiolytic and Analgesic Agents

Synthesis and Pharmacological Evaluation of Novel 2,3,4,5-tetrahydro[1,3]diazepino[1,2-<i>a</i>]benzimidazole Derivatives as Promising Anxiolytic and Analgesic Agents

A number of novel 2,3,4,5-tetrahydro[1,3]diazepino[1,2-<i>a</i>]benzimidazole derivatives <b>2</b> were obtained by alkylation mainly in the 1<i>H</i>-tautomeric form of 2,3,4,5-tetrahydro[1,3]diazepino[1,2-<i>a</i>]benzimidazole or its 8,9-dimethyl-su...

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Bibliographic Details
Main Authors: Dmitriy V. Maltsev, Alexander A. Spasov, Pavel M. Vassiliev, Maria O. Skripka, Mikhail V. Miroshnikov, Andrey N. Kochetkov, Nataliya V. Eliseeva, Yuliya V. Lifanova, Tatyana A. Kuzmenko, Lyudmila N. Divaeva, Anatolii S. Morkovnik
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Molecules
Subjects:
diazepino[1,2-<i>a</i>]benzimidazole
triazabenzo[<i>a</i>]cyclopenta[<i>cd</i>]azulenium
anxiolytic
analgesic
hot plate
open field
Online Access:https://www.mdpi.com/1420-3049/26/19/6049

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