Low-Molecular-Weight Secondary Metabolites from Fungi: <i>Cerrena unicolor</i> as a New Proposal of an Effective Preparation against <i>Rhabditis</i> Nematodes
Plants and fungi are known as a valuable source of natural medicines used in the treatment of various diseases. Many of them are used to treat human and animal gastrointestinal diseases caused by parasites. The aim of this study was to investigate for the first time the antinematode properties of ex...
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MDPI AG
2022-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/5/1660 |
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| author | Marta Ziaja-Sołtys Przemysław Kołodziej Dawid Stefaniuk Anna Matuszewska Magdalena Jaszek Anna Bogucka-Kocka |
| author_facet | Marta Ziaja-Sołtys Przemysław Kołodziej Dawid Stefaniuk Anna Matuszewska Magdalena Jaszek Anna Bogucka-Kocka |
| author_sort | Marta Ziaja-Sołtys |
| collection | DOAJ |
| description | Plants and fungi are known as a valuable source of natural medicines used in the treatment of various diseases. Many of them are used to treat human and animal gastrointestinal diseases caused by parasites. The aim of this study was to investigate for the first time the antinematode properties of extracellular low-molecular subfractions (ex-LMS) obtained from the liquid growth medium of idiophasic <i>Cerrena unicolor</i> cultures. The fungal fractions were isolated according to a procedure previously described by Jaszek et al. The in vitro tests were performed using nematodes of the <i>Rhabditis</i> genus. As demonstrated by the results, the total fraction with a molecular weight < 10 kDa (CU-A) and the 0.02–1.5 kDa fraction (CU-B) had nematicidal activity. It was found that the analyzed substances induced movement disturbances caused by the paralysis of the back part of the nematode’s body. The degree of body paralysis was proportional to the increase in the concentration of the tested fractions. Summarizing the obtained results in the context of the available literature data, it seems that <i>C. unicolor</i> may be a good new candidate for research on nematode infections. |
| first_indexed | 2024-03-09T20:29:25Z |
| format | Article |
| id | doaj.art-b539e4e097fb408eb9db44fa23bfc4a7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T20:29:25Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b539e4e097fb408eb9db44fa23bfc4a72023-11-23T23:27:50ZengMDPI AGMolecules1420-30492022-03-01275166010.3390/molecules27051660Low-Molecular-Weight Secondary Metabolites from Fungi: <i>Cerrena unicolor</i> as a New Proposal of an Effective Preparation against <i>Rhabditis</i> NematodesMarta Ziaja-Sołtys0Przemysław Kołodziej1Dawid Stefaniuk2Anna Matuszewska3Magdalena Jaszek4Anna Bogucka-Kocka5Chair and Department of Biology with Genetics, Medical University of Lublin, Witolda Chodźki Street 4A, 20-093 Lublin, PolandChair and Department of Biology with Genetics, Medical University of Lublin, Witolda Chodźki Street 4A, 20-093 Lublin, PolandDepartment of Biochemistry, Maria Curie-Skłodowska University, Akademicka Street 19, 20-033 Lublin, PolandDepartment of Biochemistry, Maria Curie-Skłodowska University, Akademicka Street 19, 20-033 Lublin, PolandDepartment of Biochemistry, Maria Curie-Skłodowska University, Akademicka Street 19, 20-033 Lublin, PolandChair and Department of Biology with Genetics, Medical University of Lublin, Witolda Chodźki Street 4A, 20-093 Lublin, PolandPlants and fungi are known as a valuable source of natural medicines used in the treatment of various diseases. Many of them are used to treat human and animal gastrointestinal diseases caused by parasites. The aim of this study was to investigate for the first time the antinematode properties of extracellular low-molecular subfractions (ex-LMS) obtained from the liquid growth medium of idiophasic <i>Cerrena unicolor</i> cultures. The fungal fractions were isolated according to a procedure previously described by Jaszek et al. The in vitro tests were performed using nematodes of the <i>Rhabditis</i> genus. As demonstrated by the results, the total fraction with a molecular weight < 10 kDa (CU-A) and the 0.02–1.5 kDa fraction (CU-B) had nematicidal activity. It was found that the analyzed substances induced movement disturbances caused by the paralysis of the back part of the nematode’s body. The degree of body paralysis was proportional to the increase in the concentration of the tested fractions. Summarizing the obtained results in the context of the available literature data, it seems that <i>C. unicolor</i> may be a good new candidate for research on nematode infections.https://www.mdpi.com/1420-3049/27/5/1660fungilow-molecular-weight metabolites<i>Nematodes</i>antiparasitic properties |
| spellingShingle | Marta Ziaja-Sołtys Przemysław Kołodziej Dawid Stefaniuk Anna Matuszewska Magdalena Jaszek Anna Bogucka-Kocka Low-Molecular-Weight Secondary Metabolites from Fungi: <i>Cerrena unicolor</i> as a New Proposal of an Effective Preparation against <i>Rhabditis</i> Nematodes Molecules fungi low-molecular-weight metabolites <i>Nematodes</i> antiparasitic properties |
| title | Low-Molecular-Weight Secondary Metabolites from Fungi: <i>Cerrena unicolor</i> as a New Proposal of an Effective Preparation against <i>Rhabditis</i> Nematodes |
| title_full | Low-Molecular-Weight Secondary Metabolites from Fungi: <i>Cerrena unicolor</i> as a New Proposal of an Effective Preparation against <i>Rhabditis</i> Nematodes |
| title_fullStr | Low-Molecular-Weight Secondary Metabolites from Fungi: <i>Cerrena unicolor</i> as a New Proposal of an Effective Preparation against <i>Rhabditis</i> Nematodes |
| title_full_unstemmed | Low-Molecular-Weight Secondary Metabolites from Fungi: <i>Cerrena unicolor</i> as a New Proposal of an Effective Preparation against <i>Rhabditis</i> Nematodes |
| title_short | Low-Molecular-Weight Secondary Metabolites from Fungi: <i>Cerrena unicolor</i> as a New Proposal of an Effective Preparation against <i>Rhabditis</i> Nematodes |
| title_sort | low molecular weight secondary metabolites from fungi i cerrena unicolor i as a new proposal of an effective preparation against i rhabditis i nematodes |
| topic | fungi low-molecular-weight metabolites <i>Nematodes</i> antiparasitic properties |
| url | https://www.mdpi.com/1420-3049/27/5/1660 |
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