Vinblastine/Methotrexate for Debilitating and Progressive Plexiform Neurofibroma in Children and Young Adults with Neurofibromatosis Type 1: A Phase 2 Study

Vinblastine/Methotrexate for Debilitating and Progressive Plexiform Neurofibroma in Children and Young Adults with Neurofibromatosis Type 1: A Phase 2 Study

Limited therapies exist for neurofibromatosis type 1 (NF1)-associated plexiform neurofibroma (PN). For this reason, the activity of vinblastine (VBL) and methotrexate (MTX) was evaluated in children and young adults with NF1 and PN. Patients ≤ 25 years of age with progressive and/or inoperable NF1-P...

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Bibliographic Details
Main Authors: Chelsea Kotch, Kristina Wagner, J. Harris Broad, Eva Dombi, Jane E. Minturn, Peter Phillips, Katherine Smith, Yimei Li, Ian N. Jacobs, Lisa M. Elden, Michael J. Fisher, Jean Belasco
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
plexiform neurofibroma
neurofibromatosis type 1
chemotherapy
clinical trial
Online Access:https://www.mdpi.com/2072-6694/15/9/2621

Internet

https://www.mdpi.com/2072-6694/15/9/2621

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