Imipramine Treatment Alters Sphingomyelin, Cholesterol, and Glycerophospholipid Metabolism in Isolated Macrophage Lysosomes

Imipramine Treatment Alters Sphingomyelin, Cholesterol, and Glycerophospholipid Metabolism in Isolated Macrophage Lysosomes

Lysosomes are degradative organelles that facilitate the removal and recycling of potentially cytotoxic materials and mediate a variety of other cellular processes, such as nutrient sensing, intracellular signaling, and lipid metabolism. Due to these central roles, lysosome dysfunction can lead to d...

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Bibliographic Details
Main Authors: Jacob M. Albright, Matthew J. Sydor, Jonathan Shannahan, Christina R. Ferreira, Andrij Holian
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Biomolecules
Subjects:
lipids
lipidomics
sphingolipids
ceramide
phosphatidylcholine
lysophosphatidylcholine
Online Access:https://www.mdpi.com/2218-273X/13/12/1732

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