Recent Advances in Nanocarrier Based Therapeutic and Diagnostic Approaches in Tuberculosis
<img src=" https://s3.amazonaws.com/production.scholastica/article/90699/large/prnano_1072023gaf.jpg?1701882189"> Tuberculosis is the second most fatal infectious disease; each year, it causes millions of deaths worldwide. Although several anti-TB drugs are currently available, the p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Andover House Inc.
2023-11-01
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| Series: | Precision Nanomedicine |
| Online Access: | https://doi.org/10.33218/001c.90699 |
| _version_ | 1797351715114057728 |
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| author | Firoz Ahmad Niharika Pandey Kratika Singh Shad Ahmad Mohd Khubaib Rolee Sharma |
| author_facet | Firoz Ahmad Niharika Pandey Kratika Singh Shad Ahmad Mohd Khubaib Rolee Sharma |
| author_sort | Firoz Ahmad |
| collection | DOAJ |
| description | <img src=" https://s3.amazonaws.com/production.scholastica/article/90699/large/prnano_1072023gaf.jpg?1701882189">
Tuberculosis is the second most fatal infectious disease; each year, it causes millions of deaths worldwide. Although several anti-TB drugs are currently available, the problem with these drugs is that they require a prolonged duration of treatment, with high drug doses. In addition, patient non-adherence to therapy subsequently leads to the development of multidrug-resistant and ex-tensively drug-resistant tuberculosis. Therefore, we need to develop an effective and robust nano-carrier-based drug delivery system to overcome these issues and improve the therapeutic potential of drug dose/duration and patient compliance. This review article focuses on the cur-rently available various nanotechnology-based therapeutic approaches, including lipid nanopar-ticles, polymeric particles, carbon nanotubes, glucan, and alginate-based nano-carrier systems for effective anti-TB drug delivery to host macrophage for mycobacterium killing. Finally, we also present some promising recent nanotechnology-based mycobacterial detection systems us-ing silver nanoparticles, silica nanoparticles, magnetic nanoparticles, quantum dots, and magnet-ic barcode assay that have recently emerged as the latest diagnostic tool. Functionalized nano-materials for emerging Aggregation-induced photodynamic therapy as next-generation theranostics have also been discussed as a novel option for TB diagnosis and therapy. |
| first_indexed | 2024-03-08T13:04:33Z |
| format | Article |
| id | doaj.art-b53fbaba0d904cc8a51edb671bab4f2d |
| institution | Directory Open Access Journal |
| issn | 2639-9431 |
| language | English |
| last_indexed | 2024-03-08T13:04:33Z |
| publishDate | 2023-11-01 |
| publisher | Andover House Inc. |
| record_format | Article |
| series | Precision Nanomedicine |
| spelling | doaj.art-b53fbaba0d904cc8a51edb671bab4f2d2024-01-18T22:42:31ZengAndover House Inc.Precision Nanomedicine2639-94312023-11-0164Recent Advances in Nanocarrier Based Therapeutic and Diagnostic Approaches in TuberculosisFiroz AhmadNiharika PandeyKratika SinghShad AhmadMohd KhubaibRolee Sharma<img src=" https://s3.amazonaws.com/production.scholastica/article/90699/large/prnano_1072023gaf.jpg?1701882189"> Tuberculosis is the second most fatal infectious disease; each year, it causes millions of deaths worldwide. Although several anti-TB drugs are currently available, the problem with these drugs is that they require a prolonged duration of treatment, with high drug doses. In addition, patient non-adherence to therapy subsequently leads to the development of multidrug-resistant and ex-tensively drug-resistant tuberculosis. Therefore, we need to develop an effective and robust nano-carrier-based drug delivery system to overcome these issues and improve the therapeutic potential of drug dose/duration and patient compliance. This review article focuses on the cur-rently available various nanotechnology-based therapeutic approaches, including lipid nanopar-ticles, polymeric particles, carbon nanotubes, glucan, and alginate-based nano-carrier systems for effective anti-TB drug delivery to host macrophage for mycobacterium killing. Finally, we also present some promising recent nanotechnology-based mycobacterial detection systems us-ing silver nanoparticles, silica nanoparticles, magnetic nanoparticles, quantum dots, and magnet-ic barcode assay that have recently emerged as the latest diagnostic tool. Functionalized nano-materials for emerging Aggregation-induced photodynamic therapy as next-generation theranostics have also been discussed as a novel option for TB diagnosis and therapy.https://doi.org/10.33218/001c.90699 |
| spellingShingle | Firoz Ahmad Niharika Pandey Kratika Singh Shad Ahmad Mohd Khubaib Rolee Sharma Recent Advances in Nanocarrier Based Therapeutic and Diagnostic Approaches in Tuberculosis Precision Nanomedicine |
| title | Recent Advances in Nanocarrier Based Therapeutic and Diagnostic Approaches in Tuberculosis |
| title_full | Recent Advances in Nanocarrier Based Therapeutic and Diagnostic Approaches in Tuberculosis |
| title_fullStr | Recent Advances in Nanocarrier Based Therapeutic and Diagnostic Approaches in Tuberculosis |
| title_full_unstemmed | Recent Advances in Nanocarrier Based Therapeutic and Diagnostic Approaches in Tuberculosis |
| title_short | Recent Advances in Nanocarrier Based Therapeutic and Diagnostic Approaches in Tuberculosis |
| title_sort | recent advances in nanocarrier based therapeutic and diagnostic approaches in tuberculosis |
| url | https://doi.org/10.33218/001c.90699 |
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