Live Triple Gene-Deleted Pseudorabies Virus-Vectored Subunit PCV2b and CSFV Vaccine Undergoes an Abortive Replication Cycle in the TG Neurons following Latency Reactivation

Live Triple Gene-Deleted Pseudorabies Virus-Vectored Subunit PCV2b and CSFV Vaccine Undergoes an Abortive Replication Cycle in the TG Neurons following Latency Reactivation

Like other alpha herpesviruses, pseudorabies virus (PRV) establishes lifelong latency in trigeminal ganglionic (TG) neurons. Upon stress, the latent viruses in the TG neurons reactivate and are transported anterograde from the neuron cell bodies to the nerve endings in the nasal mucosa, where they r...

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Bibliographic Details
Main Authors: Selvaraj Pavulraj, Rhett W. Stout, Daniel B. Paulsen, Shafiqul I. Chowdhury
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Viruses
Subjects:
pseudorabies virus
vectored vaccine
latency reactivation
thymidine kinase
glycoprotein E
triple mutant
Online Access:https://www.mdpi.com/1999-4915/15/2/473

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