Human NPCs can degrade α–syn fibrils and transfer them preferentially in a cell contact-dependent manner possibly through TNT-like structures

Human NPCs can degrade α–syn fibrils and transfer them preferentially in a cell contact-dependent manner possibly through TNT-like structures

Parkinson's disease (PD) is the second most common neurodegenerative disorder whereby loss of midbrain dopaminergic neurons results in motor dysfunction. Transplantation of human induced pluripotent stem cells (iPSCs) into the brain of patients affected by PD is one of the therapeutic approache...

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Bibliographic Details
Main Authors: Clara Grudina, Georgia Kouroupi, Takashi Nonaka, Masato Hasegawa, Rebecca Matsas, Chiara Zurzolo
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Human neuronal precursors
Alpha-synuclein
Lysosomes
TNT-like structures
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119302840

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