Effect of Paeonia suffruticosa Andr. Stamens on Rat Model of Chronic Abacterial Prostatitis
In order to investigate the pharmacological effect of Paeonia suffruticosa Andr. stamens on chronic non-bacterial prostatitis (CNBP) in rats, the rats with chronic abacterial prostatitis induced by castration combined subcutaneous injection of hormone (estradiol benzoate 0.25 mg·kg−1) were used as m...
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The editorial department of Science and Technology of Food Industry
2024-01-01
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| Series: | Shipin gongye ke-ji |
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| Online Access: | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2023030237 |
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| author | Dandan CHENG Demin GAO Daijie WANG Dong LIANG Zhiyong PANG Yazhen XU Huimin WANG Wenpeng YUAN |
| author_facet | Dandan CHENG Demin GAO Daijie WANG Dong LIANG Zhiyong PANG Yazhen XU Huimin WANG Wenpeng YUAN |
| author_sort | Dandan CHENG |
| collection | DOAJ |
| description | In order to investigate the pharmacological effect of Paeonia suffruticosa Andr. stamens on chronic non-bacterial prostatitis (CNBP) in rats, the rats with chronic abacterial prostatitis induced by castration combined subcutaneous injection of hormone (estradiol benzoate 0.25 mg·kg−1) were used as models. Forty rats with CNBP were randomly divided into five groups (8 per group): Model group (normal saline), positive group (celecoxib 250 mg·kg−1), various doses of lyophilized powder of Paeonia suffruticosa Andr. stamens groups (100, 200, 400 mg·kg−1). Another group of normal mice treated with normal saline as normal group. The therapeutic effect of Paeonia suffruticosa Andr. stamens on CNBP was evaluated by lecithin body density, prostatic index, cytokines in prostate tissue and the expression levels of TXB2 and 6-K-PGF1α in blood. The results showed that the inflammation of prostate tissue in rats was significantly improved. Compared with model group, the number of white blood cells, prostate weight, prostate index, TXB2 and the content of PGE2 in prostate tissue of rats were significantly decreased in each dosage group of Paeonia suffruticosa Andr. stamens (P<0.01, P<0.05). The contents of ICAM-1, INF-γ, TNF-α, MCP-1 and IL-8 in high-dose group of Paeonia suffruticosa Andr. stamens were significantly decreased (P<0.01, P<0.05), and in low-dose group were also decreased, but there was no significant difference (P>0.05). The contents of 6-keto-PGF1α and NO in high dose of Paeonia suffruticosa Andr. stamens were significantly increased (P<0.01, P<0.05), and in low dose group were also increased, but there was no significant difference (P>0.05). This study showed that Paeonia suffruticosa Andr. stamens had therapeutic effect on chronic abacterial prostatitis, which would provide a theoretical basis for further development and application of the Paeonia suffruticosa Andr. stamens. |
| first_indexed | 2024-03-08T14:52:44Z |
| format | Article |
| id | doaj.art-b542a50f10734d5abefab69fc6604753 |
| institution | Directory Open Access Journal |
| issn | 1002-0306 |
| language | zho |
| last_indexed | 2024-03-08T14:52:44Z |
| publishDate | 2024-01-01 |
| publisher | The editorial department of Science and Technology of Food Industry |
| record_format | Article |
| series | Shipin gongye ke-ji |
| spelling | doaj.art-b542a50f10734d5abefab69fc66047532024-01-11T01:27:35ZzhoThe editorial department of Science and Technology of Food IndustryShipin gongye ke-ji1002-03062024-01-0145234234810.13386/j.issn1002-0306.20230302372023030237-2Effect of Paeonia suffruticosa Andr. Stamens on Rat Model of Chronic Abacterial ProstatitisDandan CHENG0Demin GAO1Daijie WANG2Dong LIANG3Zhiyong PANG4Yazhen XU5Huimin WANG6Wenpeng YUAN7Heze Branch, Qilu University of Technology (Shandong Academy of Sciences), Biological Engineering Technology Innovation Center of Shandong Province, Heze 274000, ChinaSchool of Pharmacy, Shandong University of TCM, Jinan 250355, ChinaHeze Branch, Qilu University of Technology (Shandong Academy of Sciences), Biological Engineering Technology Innovation Center of Shandong Province, Heze 274000, ChinaHeze Peony Industrial Technology Research Institute, Heze 274000, ChinaHeze Peony Industrial Technology Research Institute, Heze 274000, ChinaHeze Peony Industrial Technology Research Institute, Heze 274000, ChinaHeze Branch, Qilu University of Technology (Shandong Academy of Sciences), Biological Engineering Technology Innovation Center of Shandong Province, Heze 274000, ChinaHeze Branch, Qilu University of Technology (Shandong Academy of Sciences), Biological Engineering Technology Innovation Center of Shandong Province, Heze 274000, ChinaIn order to investigate the pharmacological effect of Paeonia suffruticosa Andr. stamens on chronic non-bacterial prostatitis (CNBP) in rats, the rats with chronic abacterial prostatitis induced by castration combined subcutaneous injection of hormone (estradiol benzoate 0.25 mg·kg−1) were used as models. Forty rats with CNBP were randomly divided into five groups (8 per group): Model group (normal saline), positive group (celecoxib 250 mg·kg−1), various doses of lyophilized powder of Paeonia suffruticosa Andr. stamens groups (100, 200, 400 mg·kg−1). Another group of normal mice treated with normal saline as normal group. The therapeutic effect of Paeonia suffruticosa Andr. stamens on CNBP was evaluated by lecithin body density, prostatic index, cytokines in prostate tissue and the expression levels of TXB2 and 6-K-PGF1α in blood. The results showed that the inflammation of prostate tissue in rats was significantly improved. Compared with model group, the number of white blood cells, prostate weight, prostate index, TXB2 and the content of PGE2 in prostate tissue of rats were significantly decreased in each dosage group of Paeonia suffruticosa Andr. stamens (P<0.01, P<0.05). The contents of ICAM-1, INF-γ, TNF-α, MCP-1 and IL-8 in high-dose group of Paeonia suffruticosa Andr. stamens were significantly decreased (P<0.01, P<0.05), and in low-dose group were also decreased, but there was no significant difference (P>0.05). The contents of 6-keto-PGF1α and NO in high dose of Paeonia suffruticosa Andr. stamens were significantly increased (P<0.01, P<0.05), and in low dose group were also increased, but there was no significant difference (P>0.05). This study showed that Paeonia suffruticosa Andr. stamens had therapeutic effect on chronic abacterial prostatitis, which would provide a theoretical basis for further development and application of the Paeonia suffruticosa Andr. stamens.http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2023030237paeonia suffruticosa andr. stamenschronic nonbacterial prostatitis (cnbp)estradiol benzoateinflammatory factor |
| spellingShingle | Dandan CHENG Demin GAO Daijie WANG Dong LIANG Zhiyong PANG Yazhen XU Huimin WANG Wenpeng YUAN Effect of Paeonia suffruticosa Andr. Stamens on Rat Model of Chronic Abacterial Prostatitis Shipin gongye ke-ji paeonia suffruticosa andr. stamens chronic nonbacterial prostatitis (cnbp) estradiol benzoate inflammatory factor |
| title | Effect of Paeonia suffruticosa Andr. Stamens on Rat Model of Chronic Abacterial Prostatitis |
| title_full | Effect of Paeonia suffruticosa Andr. Stamens on Rat Model of Chronic Abacterial Prostatitis |
| title_fullStr | Effect of Paeonia suffruticosa Andr. Stamens on Rat Model of Chronic Abacterial Prostatitis |
| title_full_unstemmed | Effect of Paeonia suffruticosa Andr. Stamens on Rat Model of Chronic Abacterial Prostatitis |
| title_short | Effect of Paeonia suffruticosa Andr. Stamens on Rat Model of Chronic Abacterial Prostatitis |
| title_sort | effect of paeonia suffruticosa andr stamens on rat model of chronic abacterial prostatitis |
| topic | paeonia suffruticosa andr. stamens chronic nonbacterial prostatitis (cnbp) estradiol benzoate inflammatory factor |
| url | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2023030237 |
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