COVID-19, MERS and SARS with Concomitant Liver Injury—Systematic Review of the Existing Literature
The novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection has been predominantly linked to respiratory distress syndrome, but gastrointestinal symptoms and hepatic injury have also been reported. The mechanism of liver injury is poorly understood and may result as...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/5/1420 |
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| author | Michał Kukla Karolina Skonieczna-Żydecka Katarzyna Kotfis Dominika Maciejewska Igor Łoniewski Luis. F. Lara Monika Pazgan-Simon Ewa Stachowska Mariusz Kaczmarczyk Anastasios Koulaouzidis Wojciech Marlicz |
| author_facet | Michał Kukla Karolina Skonieczna-Żydecka Katarzyna Kotfis Dominika Maciejewska Igor Łoniewski Luis. F. Lara Monika Pazgan-Simon Ewa Stachowska Mariusz Kaczmarczyk Anastasios Koulaouzidis Wojciech Marlicz |
| author_sort | Michał Kukla |
| collection | DOAJ |
| description | The novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection has been predominantly linked to respiratory distress syndrome, but gastrointestinal symptoms and hepatic injury have also been reported. The mechanism of liver injury is poorly understood and may result as a consequence of viral hepatitis, systemic inflammatory response, gut barrier and microbiome alterations, intensive care treatment or drug toxicity. The incidence of hepatopathy among patients with coronavirus disease 2019 (COVID-19) is unclear, but studies have reported liver injury in patients with SARS and Middle East respiratory syndrome (MERS). We aimed to systematically review data on the prevalence of hepatic impairments and their clinical course in SARS and MERS <i>Coronaviridae</i> infections. A systematic literature search (PubMed/Embase/Cinahl/Web of Science) according to preferred reporting items for systematic review and meta-analysis protocols (PRISMA) was conducted from database inception until 17/03/2020 for studies that evaluated the incidence of hepatic abnormalities in SARS CoV-1, SARS CoV-2 and MERS infected patients with reported liver-related parameters. A total of forty-three studies were included. Liver anomalies were predominantly mild to moderately elevated transaminases, hypoalbuminemia and prolongation of prothrombin time. Histopathology varied between non-specific inflammation, mild steatosis, congestion and massive necrosis. More studies to elucidate the mechanism and importance of liver injury on the clinical course and prognosis in patients with novel SARS-CoV-2 infection are warranted. |
| first_indexed | 2024-03-10T19:55:47Z |
| format | Article |
| id | doaj.art-b542b9f42d2445f98580bfe02be794a6 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T19:55:47Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b542b9f42d2445f98580bfe02be794a62023-11-20T00:02:00ZengMDPI AGJournal of Clinical Medicine2077-03832020-05-0195142010.3390/jcm9051420COVID-19, MERS and SARS with Concomitant Liver Injury—Systematic Review of the Existing LiteratureMichał Kukla0Karolina Skonieczna-Żydecka1Katarzyna Kotfis2Dominika Maciejewska3Igor Łoniewski4Luis. F. Lara5Monika Pazgan-Simon6Ewa Stachowska7Mariusz Kaczmarczyk8Anastasios Koulaouzidis9Wojciech Marlicz10Department of Internal Medicine and Geriatrics, Jagiellonian University Medical College, 2 Jakubowskiego St., 30-688 Cracow, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Anaesthesiology, Intensive Therapy and Acute Intoxications, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA1st Infectious Diseases Ward, Gromkowski Regional Specialist Hospital, Wroclaw, 5 Koszarowa St., 50-149 Wroclaw, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Clinical and Molecular Biochemistry, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandCentre for Liver & Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UKDepartment of Gastroenterology, Pomeranian Medical University, 71-252 Szczecin, PolandThe novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection has been predominantly linked to respiratory distress syndrome, but gastrointestinal symptoms and hepatic injury have also been reported. The mechanism of liver injury is poorly understood and may result as a consequence of viral hepatitis, systemic inflammatory response, gut barrier and microbiome alterations, intensive care treatment or drug toxicity. The incidence of hepatopathy among patients with coronavirus disease 2019 (COVID-19) is unclear, but studies have reported liver injury in patients with SARS and Middle East respiratory syndrome (MERS). We aimed to systematically review data on the prevalence of hepatic impairments and their clinical course in SARS and MERS <i>Coronaviridae</i> infections. A systematic literature search (PubMed/Embase/Cinahl/Web of Science) according to preferred reporting items for systematic review and meta-analysis protocols (PRISMA) was conducted from database inception until 17/03/2020 for studies that evaluated the incidence of hepatic abnormalities in SARS CoV-1, SARS CoV-2 and MERS infected patients with reported liver-related parameters. A total of forty-three studies were included. Liver anomalies were predominantly mild to moderately elevated transaminases, hypoalbuminemia and prolongation of prothrombin time. Histopathology varied between non-specific inflammation, mild steatosis, congestion and massive necrosis. More studies to elucidate the mechanism and importance of liver injury on the clinical course and prognosis in patients with novel SARS-CoV-2 infection are warranted.https://www.mdpi.com/2077-0383/9/5/1420SARS-CoV-2coronavirusliverpandemicSARSMERS |
| spellingShingle | Michał Kukla Karolina Skonieczna-Żydecka Katarzyna Kotfis Dominika Maciejewska Igor Łoniewski Luis. F. Lara Monika Pazgan-Simon Ewa Stachowska Mariusz Kaczmarczyk Anastasios Koulaouzidis Wojciech Marlicz COVID-19, MERS and SARS with Concomitant Liver Injury—Systematic Review of the Existing Literature Journal of Clinical Medicine SARS-CoV-2 coronavirus liver pandemic SARS MERS |
| title | COVID-19, MERS and SARS with Concomitant Liver Injury—Systematic Review of the Existing Literature |
| title_full | COVID-19, MERS and SARS with Concomitant Liver Injury—Systematic Review of the Existing Literature |
| title_fullStr | COVID-19, MERS and SARS with Concomitant Liver Injury—Systematic Review of the Existing Literature |
| title_full_unstemmed | COVID-19, MERS and SARS with Concomitant Liver Injury—Systematic Review of the Existing Literature |
| title_short | COVID-19, MERS and SARS with Concomitant Liver Injury—Systematic Review of the Existing Literature |
| title_sort | covid 19 mers and sars with concomitant liver injury systematic review of the existing literature |
| topic | SARS-CoV-2 coronavirus liver pandemic SARS MERS |
| url | https://www.mdpi.com/2077-0383/9/5/1420 |
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