Association Between Serum Creatinine Concentrations and Overall Survival in Patients With Colorectal Cancer: A Multi-Center Cohort Study
BackgroundColorectal cancer (CRC) is one of the most common malignancies throughout the world, with high rates of morbidity and mortality. Previous studies reported that serum creatinine (Scr) concentrations were associated with overall survival (OS) in cancer patients, but little is known about the...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-10-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.710423/full |
| _version_ | 1830343203356672000 |
|---|---|
| author | Ming Yang Ming Yang Ming Yang Ming Yang Qi Zhang Qi Zhang Qi Zhang Qi Zhang Guo-Tian Ruan Guo-Tian Ruan Guo-Tian Ruan Guo-Tian Ruan Meng Tang Meng Tang Meng Tang Meng Tang Xi Zhang Xi Zhang Xi Zhang Xi Zhang Meng-Meng Song Meng-Meng Song Meng-Meng Song Meng-Meng Song Xiao-Wei Zhang Xiao-Wei Zhang Xiao-Wei Zhang Xiao-Wei Zhang Kang-Ping Zhang Kang-Ping Zhang Kang-Ping Zhang Kang-Ping Zhang Yi-Zhong Ge Yi-Zhong Ge Yi-Zhong Ge Yi-Zhong Ge Yi-Zhong Ge Han-Ping Shi Han-Ping Shi Han-Ping Shi Han-Ping Shi |
| author_facet | Ming Yang Ming Yang Ming Yang Ming Yang Qi Zhang Qi Zhang Qi Zhang Qi Zhang Guo-Tian Ruan Guo-Tian Ruan Guo-Tian Ruan Guo-Tian Ruan Meng Tang Meng Tang Meng Tang Meng Tang Xi Zhang Xi Zhang Xi Zhang Xi Zhang Meng-Meng Song Meng-Meng Song Meng-Meng Song Meng-Meng Song Xiao-Wei Zhang Xiao-Wei Zhang Xiao-Wei Zhang Xiao-Wei Zhang Kang-Ping Zhang Kang-Ping Zhang Kang-Ping Zhang Kang-Ping Zhang Yi-Zhong Ge Yi-Zhong Ge Yi-Zhong Ge Yi-Zhong Ge Yi-Zhong Ge Han-Ping Shi Han-Ping Shi Han-Ping Shi Han-Ping Shi |
| author_sort | Ming Yang |
| collection | DOAJ |
| description | BackgroundColorectal cancer (CRC) is one of the most common malignancies throughout the world, with high rates of morbidity and mortality. Previous studies reported that serum creatinine (Scr) concentrations were associated with overall survival (OS) in cancer patients, but little is known about the association between Scr and OS in patients with CRC. This study investigated the relationship between Scr concentrations and OS in patients with CRC and examined possible effect modifiers.MethodsA retrospective cohort, including 1,733 patients with CRC, was established from a multi-center clinical study. Patients were divided into low (<71 μmol/L in men or <59 μmol/L in women), normal (71-104 μmol/L in men or 59-85 μmol/L in women) and high (>104 μmol/L in men or >85 μmol/L in women) Scr groups. Cox regression analysis was used to examine association between Scr concentrations and OS. Stratified (subgroup) analyses were used to examine men and women separately. Interaction tests were used to evaluate associations between each variable and OS, as well as possible interactions of these variables with Scr levels. Cross-classified analyses were used only in men.ResultsPatients with low [hazard ratio (HR) = 1.43, 95% confidence interval (CI) = 1.19-1.72; P < 0.001] or high (HR = 1.89, 95% CI = 1.36-2.63; P < 0.001) Scr level had a significantly lower OS than patients with normal Scr levels. Significant interactions with Scr concentrations were observed for body mass index (P for interaction = 0.019) in men.ConclusionLow or high Scr concentration is associated with significantly lower OS in patients with CRC. Future study is warranted to investigate the underlying mechanism. |
| first_indexed | 2024-12-19T22:03:48Z |
| format | Article |
| id | doaj.art-b5442706f64c49abb0d48eda3d747641 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-19T22:03:48Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b5442706f64c49abb0d48eda3d7476412022-12-21T20:04:04ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-10-011110.3389/fonc.2021.710423710423Association Between Serum Creatinine Concentrations and Overall Survival in Patients With Colorectal Cancer: A Multi-Center Cohort StudyMing Yang0Ming Yang1Ming Yang2Ming Yang3Qi Zhang4Qi Zhang5Qi Zhang6Qi Zhang7Guo-Tian Ruan8Guo-Tian Ruan9Guo-Tian Ruan10Guo-Tian Ruan11Meng Tang12Meng Tang13Meng Tang14Meng Tang15Xi Zhang16Xi Zhang17Xi Zhang18Xi Zhang19Meng-Meng Song20Meng-Meng Song21Meng-Meng Song22Meng-Meng Song23Xiao-Wei Zhang24Xiao-Wei Zhang25Xiao-Wei Zhang26Xiao-Wei Zhang27Kang-Ping Zhang28Kang-Ping Zhang29Kang-Ping Zhang30Kang-Ping Zhang31Yi-Zhong Ge32Yi-Zhong Ge33Yi-Zhong Ge34Yi-Zhong Ge35Yi-Zhong Ge36Han-Ping Shi37Han-Ping Shi38Han-Ping Shi39Han-Ping Shi40Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Oncology, Capital Medical University, Beijing, ChinaLaboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, ChinaDepartment of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Oncology, Capital Medical University, Beijing, ChinaLaboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, ChinaDepartment of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Oncology, Capital Medical University, Beijing, ChinaLaboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, ChinaDepartment of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Oncology, Capital Medical University, Beijing, ChinaLaboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, ChinaDepartment of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Oncology, Capital Medical University, Beijing, ChinaLaboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, ChinaDepartment of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Oncology, Capital Medical University, Beijing, ChinaLaboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, ChinaDepartment of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Oncology, Capital Medical University, Beijing, ChinaLaboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, ChinaDepartment of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Oncology, Capital Medical University, Beijing, ChinaLaboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, ChinaDepartment of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Oncology, Capital Medical University, Beijing, ChinaLaboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, ChinaDepartment of Cancer Radiotherapy and Chemotherapy, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Oncology, Capital Medical University, Beijing, ChinaLaboratory of Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, ChinaBackgroundColorectal cancer (CRC) is one of the most common malignancies throughout the world, with high rates of morbidity and mortality. Previous studies reported that serum creatinine (Scr) concentrations were associated with overall survival (OS) in cancer patients, but little is known about the association between Scr and OS in patients with CRC. This study investigated the relationship between Scr concentrations and OS in patients with CRC and examined possible effect modifiers.MethodsA retrospective cohort, including 1,733 patients with CRC, was established from a multi-center clinical study. Patients were divided into low (<71 μmol/L in men or <59 μmol/L in women), normal (71-104 μmol/L in men or 59-85 μmol/L in women) and high (>104 μmol/L in men or >85 μmol/L in women) Scr groups. Cox regression analysis was used to examine association between Scr concentrations and OS. Stratified (subgroup) analyses were used to examine men and women separately. Interaction tests were used to evaluate associations between each variable and OS, as well as possible interactions of these variables with Scr levels. Cross-classified analyses were used only in men.ResultsPatients with low [hazard ratio (HR) = 1.43, 95% confidence interval (CI) = 1.19-1.72; P < 0.001] or high (HR = 1.89, 95% CI = 1.36-2.63; P < 0.001) Scr level had a significantly lower OS than patients with normal Scr levels. Significant interactions with Scr concentrations were observed for body mass index (P for interaction = 0.019) in men.ConclusionLow or high Scr concentration is associated with significantly lower OS in patients with CRC. Future study is warranted to investigate the underlying mechanism.https://www.frontiersin.org/articles/10.3389/fonc.2021.710423/fullcolorectal cancerserum creatinineoverall survivalrenal functionmuscle loss |
| spellingShingle | Ming Yang Ming Yang Ming Yang Ming Yang Qi Zhang Qi Zhang Qi Zhang Qi Zhang Guo-Tian Ruan Guo-Tian Ruan Guo-Tian Ruan Guo-Tian Ruan Meng Tang Meng Tang Meng Tang Meng Tang Xi Zhang Xi Zhang Xi Zhang Xi Zhang Meng-Meng Song Meng-Meng Song Meng-Meng Song Meng-Meng Song Xiao-Wei Zhang Xiao-Wei Zhang Xiao-Wei Zhang Xiao-Wei Zhang Kang-Ping Zhang Kang-Ping Zhang Kang-Ping Zhang Kang-Ping Zhang Yi-Zhong Ge Yi-Zhong Ge Yi-Zhong Ge Yi-Zhong Ge Yi-Zhong Ge Han-Ping Shi Han-Ping Shi Han-Ping Shi Han-Ping Shi Association Between Serum Creatinine Concentrations and Overall Survival in Patients With Colorectal Cancer: A Multi-Center Cohort Study Frontiers in Oncology colorectal cancer serum creatinine overall survival renal function muscle loss |
| title | Association Between Serum Creatinine Concentrations and Overall Survival in Patients With Colorectal Cancer: A Multi-Center Cohort Study |
| title_full | Association Between Serum Creatinine Concentrations and Overall Survival in Patients With Colorectal Cancer: A Multi-Center Cohort Study |
| title_fullStr | Association Between Serum Creatinine Concentrations and Overall Survival in Patients With Colorectal Cancer: A Multi-Center Cohort Study |
| title_full_unstemmed | Association Between Serum Creatinine Concentrations and Overall Survival in Patients With Colorectal Cancer: A Multi-Center Cohort Study |
| title_short | Association Between Serum Creatinine Concentrations and Overall Survival in Patients With Colorectal Cancer: A Multi-Center Cohort Study |
| title_sort | association between serum creatinine concentrations and overall survival in patients with colorectal cancer a multi center cohort study |
| topic | colorectal cancer serum creatinine overall survival renal function muscle loss |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.710423/full |
| work_keys_str_mv | AT mingyang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT mingyang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT mingyang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT mingyang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT qizhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT qizhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT qizhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT qizhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT guotianruan associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT guotianruan associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT guotianruan associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT guotianruan associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT mengtang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT mengtang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT mengtang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT mengtang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT xizhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT xizhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT xizhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT xizhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT mengmengsong associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT mengmengsong associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT mengmengsong associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT mengmengsong associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT xiaoweizhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT xiaoweizhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT xiaoweizhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT xiaoweizhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT kangpingzhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT kangpingzhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT kangpingzhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT kangpingzhang associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT yizhongge associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT yizhongge associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT yizhongge associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT yizhongge associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT yizhongge associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT hanpingshi associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT hanpingshi associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT hanpingshi associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy AT hanpingshi associationbetweenserumcreatinineconcentrationsandoverallsurvivalinpatientswithcolorectalcanceramulticentercohortstudy |