Current Status and Prospects of Targeted Therapy for Osteosarcoma
Osteosarcoma (OS) is a highly malignant tumor occurring in bone tissue with a high propensity to metastasize, and its underlying mechanisms remain largely elusive. The OS prognosis is poor, and improving the survival of OS patients remains a challenge. Current treatment methods such as surgical appr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/21/3507 |
| _version_ | 1797468733973725184 |
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| author | Zunguo Hu Shuang Wen Zijun Huo Qing Wang Jiantao Zhao Zihao Wang Yanchun Chen Lingyun Zhang Fenghua Zhou Zhangyu Guo Huancai Liu Shuanhu Zhou |
| author_facet | Zunguo Hu Shuang Wen Zijun Huo Qing Wang Jiantao Zhao Zihao Wang Yanchun Chen Lingyun Zhang Fenghua Zhou Zhangyu Guo Huancai Liu Shuanhu Zhou |
| author_sort | Zunguo Hu |
| collection | DOAJ |
| description | Osteosarcoma (OS) is a highly malignant tumor occurring in bone tissue with a high propensity to metastasize, and its underlying mechanisms remain largely elusive. The OS prognosis is poor, and improving the survival of OS patients remains a challenge. Current treatment methods such as surgical approaches, chemotherapeutic drugs, and immunotherapeutic drugs remain ineffective. As research progresses, targeted therapy is gradually becoming irreplaceable. In this review, several treatment modalities for osteosarcoma, such as surgery, chemotherapy, and immunotherapy, are briefly described, followed by a discussion of targeted therapy, the important targets, and new technologies for osteosarcoma treatment. |
| first_indexed | 2024-03-09T19:11:37Z |
| format | Article |
| id | doaj.art-b5449776fd0e40339c65762555349e70 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T19:11:37Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b5449776fd0e40339c65762555349e702023-11-24T04:09:54ZengMDPI AGCells2073-44092022-11-011121350710.3390/cells11213507Current Status and Prospects of Targeted Therapy for OsteosarcomaZunguo Hu0Shuang Wen1Zijun Huo2Qing Wang3Jiantao Zhao4Zihao Wang5Yanchun Chen6Lingyun Zhang7Fenghua Zhou8Zhangyu Guo9Huancai Liu10Shuanhu Zhou11Department of Joint Surgery, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang 261061, ChinaDepartment of Joint Surgery, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang 261061, ChinaDepartment of Histology and Embryology, School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, ChinaNeurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, ChinaDepartment of Joint Surgery, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang 261061, ChinaDepartment of Histology and Embryology, School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, ChinaNeurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaNeurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaNeurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaDepartment of Joint Surgery, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang 261061, ChinaDepartment of Orthopedic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USAOsteosarcoma (OS) is a highly malignant tumor occurring in bone tissue with a high propensity to metastasize, and its underlying mechanisms remain largely elusive. The OS prognosis is poor, and improving the survival of OS patients remains a challenge. Current treatment methods such as surgical approaches, chemotherapeutic drugs, and immunotherapeutic drugs remain ineffective. As research progresses, targeted therapy is gradually becoming irreplaceable. In this review, several treatment modalities for osteosarcoma, such as surgery, chemotherapy, and immunotherapy, are briefly described, followed by a discussion of targeted therapy, the important targets, and new technologies for osteosarcoma treatment.https://www.mdpi.com/2073-4409/11/21/3507osteosarcomatargeted therapychemotherapysurgical treatment |
| spellingShingle | Zunguo Hu Shuang Wen Zijun Huo Qing Wang Jiantao Zhao Zihao Wang Yanchun Chen Lingyun Zhang Fenghua Zhou Zhangyu Guo Huancai Liu Shuanhu Zhou Current Status and Prospects of Targeted Therapy for Osteosarcoma Cells osteosarcoma targeted therapy chemotherapy surgical treatment |
| title | Current Status and Prospects of Targeted Therapy for Osteosarcoma |
| title_full | Current Status and Prospects of Targeted Therapy for Osteosarcoma |
| title_fullStr | Current Status and Prospects of Targeted Therapy for Osteosarcoma |
| title_full_unstemmed | Current Status and Prospects of Targeted Therapy for Osteosarcoma |
| title_short | Current Status and Prospects of Targeted Therapy for Osteosarcoma |
| title_sort | current status and prospects of targeted therapy for osteosarcoma |
| topic | osteosarcoma targeted therapy chemotherapy surgical treatment |
| url | https://www.mdpi.com/2073-4409/11/21/3507 |
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