Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects
<p>Abstract</p> <p>Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2006-02-01
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| Series: | AIDS Research and Therapy |
| Online Access: | http://www.aidsrestherapy.com/content/3/1/5 |
| _version_ | 1818937114680623104 |
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| author | Linares Rafael Rodgers Tatanisha Venketaraman Vishwanath Reilly Nancy Swaminathan Shobha Hom David Millman Ariel C Wallis Robert Connell Nancy D |
| author_facet | Linares Rafael Rodgers Tatanisha Venketaraman Vishwanath Reilly Nancy Swaminathan Shobha Hom David Millman Ariel C Wallis Robert Connell Nancy D |
| author_sort | Linares Rafael |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione in immunity against tuberculosis infection in samples derived from healthy and human immunodeficiency virus infected subjects. Our studies confirm that glutathione levels are reduced in peripheral blood mononuclear cells and in red blood cells isolated from human immunodeficiency virus-infected subjects (CD4>400/cumm). Furthermore, treatment of blood cultures from human immunodeficiency virus infected subjects with N-acetyl cysteine, a glutathione precursor, caused improved control of intracellular <it>M. tuberculosis </it>infection. N-acetyl cysteine treatment decreased the levels of IL-1, TNF-α, and IL-6, and increased the levels of IFN-γ in blood cultures derived from human immunodeficiency virus-infected subjects, promoting the host immune responses to contain <it>M. tuberculosis </it>infection successfully.</p> |
| first_indexed | 2024-12-20T05:46:49Z |
| format | Article |
| id | doaj.art-b544af36f0a340788da2ed595944e61a |
| institution | Directory Open Access Journal |
| issn | 1742-6405 |
| language | English |
| last_indexed | 2024-12-20T05:46:49Z |
| publishDate | 2006-02-01 |
| publisher | BMC |
| record_format | Article |
| series | AIDS Research and Therapy |
| spelling | doaj.art-b544af36f0a340788da2ed595944e61a2022-12-21T19:51:17ZengBMCAIDS Research and Therapy1742-64052006-02-0131510.1186/1742-6405-3-5Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjectsLinares RafaelRodgers TatanishaVenketaraman VishwanathReilly NancySwaminathan ShobhaHom DavidMillman Ariel CWallis RobertConnell Nancy D<p>Abstract</p> <p>Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione in immunity against tuberculosis infection in samples derived from healthy and human immunodeficiency virus infected subjects. Our studies confirm that glutathione levels are reduced in peripheral blood mononuclear cells and in red blood cells isolated from human immunodeficiency virus-infected subjects (CD4>400/cumm). Furthermore, treatment of blood cultures from human immunodeficiency virus infected subjects with N-acetyl cysteine, a glutathione precursor, caused improved control of intracellular <it>M. tuberculosis </it>infection. N-acetyl cysteine treatment decreased the levels of IL-1, TNF-α, and IL-6, and increased the levels of IFN-γ in blood cultures derived from human immunodeficiency virus-infected subjects, promoting the host immune responses to contain <it>M. tuberculosis </it>infection successfully.</p>http://www.aidsrestherapy.com/content/3/1/5 |
| spellingShingle | Linares Rafael Rodgers Tatanisha Venketaraman Vishwanath Reilly Nancy Swaminathan Shobha Hom David Millman Ariel C Wallis Robert Connell Nancy D Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects AIDS Research and Therapy |
| title | Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects |
| title_full | Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects |
| title_fullStr | Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects |
| title_full_unstemmed | Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects |
| title_short | Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects |
| title_sort | glutathione and growth inhibition of mycobacterium tuberculosis in healthy and hiv infected subjects |
| url | http://www.aidsrestherapy.com/content/3/1/5 |
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