Discovery of TIGIT inhibitors based on DEL and machine learning

Discovery of TIGIT inhibitors based on DEL and machine learning

Drug discovery has entered a new period of vigorous development with advanced technologies such as DNA-encoded library (DEL) and artificial intelligence (AI). The previous DEL-AI combination has been successfully applied in the drug discovery of classical kinase and receptor targets mainly based on...

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Bibliographic Details
Main Authors: Feng Xiong, Mingao Yu, Honggui Xu, Zhenmin Zhong, Zhenwei Li, Yuhan Guo, Tianyuan Zhang, Zhixuan Zeng, Feng Jin, Xun He
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Chemistry
Subjects:
DNA-encoded library
machine learning
protein-protein interaction
TIGIT
anti-tumor
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.982539/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.982539/full

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