Cardiac Hypertrophy Is Associated With Advanced Brain Aging in the General Population
Background Hypertrophy of the left ventricle (LV) has recently been associated with adverse changes of brain structure in older adults, notably increased burden of white matter hyperintensities (WMHs). Whether greater LV size or mass is also related to WMH burden in middle‐aged adults is currently u...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-09-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.121.020994 |
| _version_ | 1819143691484266496 |
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| author | Stefan Frenzel Katharina Wittfeld Robin Bülow Henry Völzke Nele Friedrich Mohamad Habes Stephan B. Felix Marcus Dörr Hans J. Grabe Martin Bahls |
| author_facet | Stefan Frenzel Katharina Wittfeld Robin Bülow Henry Völzke Nele Friedrich Mohamad Habes Stephan B. Felix Marcus Dörr Hans J. Grabe Martin Bahls |
| author_sort | Stefan Frenzel |
| collection | DOAJ |
| description | Background Hypertrophy of the left ventricle (LV) has recently been associated with adverse changes of brain structure in older adults, notably increased burden of white matter hyperintensities (WMHs). Whether greater LV size or mass is also related to WMH burden in middle‐aged adults is currently unclear. In addition, its relation with alterations in cortical thickness (CT) has not been studied to date. Methods and Results Data from 1602 participants of the population‐based SHIP (Study of Health in Pomerania) with LV ejection fraction >40% and no history of myocardial infarction were included (aged 21–82 years; median age, 49 years; 53% women). Participants underwent both echocardiography and magnetic resonance imaging of the head. Imaging markers of brain aging (ie, CT and WMH volume) were determined from magnetic resonance imaging scans. LV mass and diameter were associated with lower global CT and greater WMH volume, while adjusting for age, sex, body height, fat‐free body mass, and intracranial volume. Moreover, thicknesses of the interventricular septum and posterior wall were also associated with lower global CT. These associations could not be explained by cardiovascular risk factors (including hypertension), inflammatory markers, or sociodemographic factors. Regional analyses showed distinct spatial patterns of lower CT in association with LV diameter and posterior wall thickness. Conclusions LV diameter and mass are associated with lower global and regional CT as well as greater WMH burden in the general population. These findings highlight the brain structural underpinnings of the associations of LV hypertrophy with cognitive decline and dementia. |
| first_indexed | 2024-12-22T12:30:16Z |
| format | Article |
| id | doaj.art-b5456eba4fc74d1d953d96f23c8e64d8 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-22T12:30:16Z |
| publishDate | 2021-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-b5456eba4fc74d1d953d96f23c8e64d82022-12-21T18:25:41ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802021-09-01101710.1161/JAHA.121.020994Cardiac Hypertrophy Is Associated With Advanced Brain Aging in the General PopulationStefan Frenzel0Katharina Wittfeld1Robin Bülow2Henry Völzke3Nele Friedrich4Mohamad Habes5Stephan B. Felix6Marcus Dörr7Hans J. Grabe8Martin Bahls9Department of Psychiatry and Psychotherapy University Medicine Greifswald Greifswald GermanyDepartment of Psychiatry and Psychotherapy University Medicine Greifswald Greifswald GermanyInstitute of Diagnostic Radiology and Neuroradiology University Medicine Greifswald Greifswald GermanyInstitute for Community Medicine University Medicine Greifswald Greifswald GermanyGerman Centre for Cardiovascular Research (DZHK), Partner Site Greifswald Greifswald GermanyNeuroimage Analytics Laboratory (NAL) and the Biggs Institute Neuroimaging Core (BINC) Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases University of Texas Health Science Center San Antonio (UTHSCSA) San Antonio TXGerman Centre for Cardiovascular Research (DZHK), Partner Site Greifswald Greifswald GermanyGerman Centre for Cardiovascular Research (DZHK), Partner Site Greifswald Greifswald GermanyDepartment of Psychiatry and Psychotherapy University Medicine Greifswald Greifswald GermanyGerman Centre for Cardiovascular Research (DZHK), Partner Site Greifswald Greifswald GermanyBackground Hypertrophy of the left ventricle (LV) has recently been associated with adverse changes of brain structure in older adults, notably increased burden of white matter hyperintensities (WMHs). Whether greater LV size or mass is also related to WMH burden in middle‐aged adults is currently unclear. In addition, its relation with alterations in cortical thickness (CT) has not been studied to date. Methods and Results Data from 1602 participants of the population‐based SHIP (Study of Health in Pomerania) with LV ejection fraction >40% and no history of myocardial infarction were included (aged 21–82 years; median age, 49 years; 53% women). Participants underwent both echocardiography and magnetic resonance imaging of the head. Imaging markers of brain aging (ie, CT and WMH volume) were determined from magnetic resonance imaging scans. LV mass and diameter were associated with lower global CT and greater WMH volume, while adjusting for age, sex, body height, fat‐free body mass, and intracranial volume. Moreover, thicknesses of the interventricular septum and posterior wall were also associated with lower global CT. These associations could not be explained by cardiovascular risk factors (including hypertension), inflammatory markers, or sociodemographic factors. Regional analyses showed distinct spatial patterns of lower CT in association with LV diameter and posterior wall thickness. Conclusions LV diameter and mass are associated with lower global and regional CT as well as greater WMH burden in the general population. These findings highlight the brain structural underpinnings of the associations of LV hypertrophy with cognitive decline and dementia.https://www.ahajournals.org/doi/10.1161/JAHA.121.020994brain imagingepidemiologyleft ventricular hypertrophy |
| spellingShingle | Stefan Frenzel Katharina Wittfeld Robin Bülow Henry Völzke Nele Friedrich Mohamad Habes Stephan B. Felix Marcus Dörr Hans J. Grabe Martin Bahls Cardiac Hypertrophy Is Associated With Advanced Brain Aging in the General Population Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease brain imaging epidemiology left ventricular hypertrophy |
| title | Cardiac Hypertrophy Is Associated With Advanced Brain Aging in the General Population |
| title_full | Cardiac Hypertrophy Is Associated With Advanced Brain Aging in the General Population |
| title_fullStr | Cardiac Hypertrophy Is Associated With Advanced Brain Aging in the General Population |
| title_full_unstemmed | Cardiac Hypertrophy Is Associated With Advanced Brain Aging in the General Population |
| title_short | Cardiac Hypertrophy Is Associated With Advanced Brain Aging in the General Population |
| title_sort | cardiac hypertrophy is associated with advanced brain aging in the general population |
| topic | brain imaging epidemiology left ventricular hypertrophy |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.121.020994 |
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