Serum Osteopontin Level Is Positively Associated with Aortic Stiffness in Patients with Peritoneal Dialysis
Background: Osteopontin (OPN) is regarded as a proinflammatory and proatherogenic molecule related to atherosclerosis. We aimed to evaluate the relationship between serum OPN and aortic stiffness (AS) of peritoneal dialysis (PD) patients. Methods: OPN and carotid-femoral pulse wave velocity (cfPWV)...
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MDPI AG
2022-03-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/3/397 |
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| author | Kai-Hsiang Chang Chih-Hsien Wang Bang-Gee Hsu Jen-Pi Tsai |
| author_facet | Kai-Hsiang Chang Chih-Hsien Wang Bang-Gee Hsu Jen-Pi Tsai |
| author_sort | Kai-Hsiang Chang |
| collection | DOAJ |
| description | Background: Osteopontin (OPN) is regarded as a proinflammatory and proatherogenic molecule related to atherosclerosis. We aimed to evaluate the relationship between serum OPN and aortic stiffness (AS) of peritoneal dialysis (PD) patients. Methods: OPN and carotid-femoral pulse wave velocity (cfPWV) were measured by a commercial enzyme-linked immunosorbent assay kit and a validated tonometry system, respectively. Patients with cfPWV > 10 m/s were designated into the AS group. Results: Twenty-two patients (31.4%) were segregated into the AS group. Multivariate linear and logistic regression analysis showed that OPN was significantly related to cfPWV and was an independent predictor of AS. The receiver operating characteristic curve analysis showed that OPN was correlated with AS with an area under the curve of 0.903 (95% CI 0.809–0.961, <i>p</i> < 0.001). Conclusions: For PD patients, the serum OPN level was correlated with cfPWV and could play an important role in the process of AS. |
| first_indexed | 2024-03-09T13:34:26Z |
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| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T13:34:26Z |
| publishDate | 2022-03-01 |
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| spelling | doaj.art-b546ed57fb6a4ea1b74aa603d4f2a7052023-11-30T21:14:08ZengMDPI AGLife2075-17292022-03-0112339710.3390/life12030397Serum Osteopontin Level Is Positively Associated with Aortic Stiffness in Patients with Peritoneal DialysisKai-Hsiang Chang0Chih-Hsien Wang1Bang-Gee Hsu2Jen-Pi Tsai3Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, TaiwanDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, TaiwanDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, TaiwanDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, TaiwanBackground: Osteopontin (OPN) is regarded as a proinflammatory and proatherogenic molecule related to atherosclerosis. We aimed to evaluate the relationship between serum OPN and aortic stiffness (AS) of peritoneal dialysis (PD) patients. Methods: OPN and carotid-femoral pulse wave velocity (cfPWV) were measured by a commercial enzyme-linked immunosorbent assay kit and a validated tonometry system, respectively. Patients with cfPWV > 10 m/s were designated into the AS group. Results: Twenty-two patients (31.4%) were segregated into the AS group. Multivariate linear and logistic regression analysis showed that OPN was significantly related to cfPWV and was an independent predictor of AS. The receiver operating characteristic curve analysis showed that OPN was correlated with AS with an area under the curve of 0.903 (95% CI 0.809–0.961, <i>p</i> < 0.001). Conclusions: For PD patients, the serum OPN level was correlated with cfPWV and could play an important role in the process of AS.https://www.mdpi.com/2075-1729/12/3/397arterial stiffnesscarotid–femoral pulse wave velocityosteopontinperitoneal dialysis |
| spellingShingle | Kai-Hsiang Chang Chih-Hsien Wang Bang-Gee Hsu Jen-Pi Tsai Serum Osteopontin Level Is Positively Associated with Aortic Stiffness in Patients with Peritoneal Dialysis Life arterial stiffness carotid–femoral pulse wave velocity osteopontin peritoneal dialysis |
| title | Serum Osteopontin Level Is Positively Associated with Aortic Stiffness in Patients with Peritoneal Dialysis |
| title_full | Serum Osteopontin Level Is Positively Associated with Aortic Stiffness in Patients with Peritoneal Dialysis |
| title_fullStr | Serum Osteopontin Level Is Positively Associated with Aortic Stiffness in Patients with Peritoneal Dialysis |
| title_full_unstemmed | Serum Osteopontin Level Is Positively Associated with Aortic Stiffness in Patients with Peritoneal Dialysis |
| title_short | Serum Osteopontin Level Is Positively Associated with Aortic Stiffness in Patients with Peritoneal Dialysis |
| title_sort | serum osteopontin level is positively associated with aortic stiffness in patients with peritoneal dialysis |
| topic | arterial stiffness carotid–femoral pulse wave velocity osteopontin peritoneal dialysis |
| url | https://www.mdpi.com/2075-1729/12/3/397 |
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