Signaling Downstream of Focal Adhesions Regulates Stiffness-Dependent Differences in the TGF-β1-Mediated Myofibroblast Differentiation of Corneal Keratocytes

Signaling Downstream of Focal Adhesions Regulates Stiffness-Dependent Differences in the TGF-β1-Mediated Myofibroblast Differentiation of Corneal Keratocytes

Following injury and refractive surgery, corneal wound healing can initiate a protracted fibrotic response that interferes with ocular function. This fibrosis is related, in part, to the myofibroblast differentiation of corneal keratocytes in response to transforming growth factor beta 1 (TGF-β1). P...

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Bibliographic Details
Main Authors: Daniel P. Maruri, Krithika S. Iyer, David W. Schmidtke, W. Matthew Petroll, Victor D. Varner
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TGF-β1
extracellular matrix
traction force microscopy
FAK
mechanobiology
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.886759/full

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