Comprehensive Characterization of Humoral Correlates of Human Immunodeficiency Virus 1 Superinfection Acquisition in High-risk Kenyan Women
HIV-1 superinfection, in which an infected individual acquires a second HIV-1 infection from a different partner, is one of the only settings in which HIV acquisition occurs in the context of a pre-existing immune response to natural HIV infection. There is evidence that initial infection provides s...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-04-01
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| Series: | EBioMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396417301469 |
| _version_ | 1819043458817458176 |
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| author | Keshet Ronen Adam S. Dingens Susan M. Graham Walter Jaoko Kishor Mandaliya R. Scott McClelland Julie Overbaugh |
| author_facet | Keshet Ronen Adam S. Dingens Susan M. Graham Walter Jaoko Kishor Mandaliya R. Scott McClelland Julie Overbaugh |
| author_sort | Keshet Ronen |
| collection | DOAJ |
| description | HIV-1 superinfection, in which an infected individual acquires a second HIV-1 infection from a different partner, is one of the only settings in which HIV acquisition occurs in the context of a pre-existing immune response to natural HIV infection. There is evidence that initial infection provides some protection from superinfection, particularly after 6 months of initial infection, when development of broad immunity occurs. Comparison of the immune response of superinfected individuals at the time of superinfection acquisition to that of individuals who remain singly infected despite continued exposure can shed light on immune correlates of HIV acquisition to inform prophylactic vaccine design. We evaluated a panel of humoral immune responses in the largest published group of superinfected individuals (n = 21), compared to a set of 3:1 matched singly infected controls from the same cohort. The immune functions studied included plasma neutralization, plasma and cervical antibody-dependent cellular cytotoxicity, and plasma IgG and IgA binding to a panel of 18 envelope antigens, including correlates of HIV acquisition in the RV144 vaccine trial, IgG binding to V1V2 and IgA binding to gp140. Association between each immune function and HIV superinfection was evaluated using conditional logistic regression. No significant associations were detected between any of the immune functions and superinfection acquisition. This study constitutes the most comprehensive and detailed characterization of multiple immune correlates of superinfection to date. The results suggest that immune responses not commonly measured in current HIV studies may be important in protection from HIV infection, and these or a more robust humoral response than that seen in naturally infected women may be needed for a protective vaccine. |
| first_indexed | 2024-12-21T09:57:07Z |
| format | Article |
| id | doaj.art-b5477b3bbd3f476cac391cc470ef03e8 |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-21T09:57:07Z |
| publishDate | 2017-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-b5477b3bbd3f476cac391cc470ef03e82022-12-21T19:08:03ZengElsevierEBioMedicine2352-39642017-04-0118C21622410.1016/j.ebiom.2017.04.005Comprehensive Characterization of Humoral Correlates of Human Immunodeficiency Virus 1 Superinfection Acquisition in High-risk Kenyan WomenKeshet Ronen0Adam S. Dingens1Susan M. Graham2Walter Jaoko3Kishor Mandaliya4R. Scott McClelland5Julie Overbaugh6Human Biology Division, Fred Hutch Cancer Research Center, 1100 Fairview Ave N., Seattle, WA 98109, USAHuman Biology Division, Fred Hutch Cancer Research Center, 1100 Fairview Ave N., Seattle, WA 98109, USADepartment of Global Health, University of Washington, 325 9th Avenue, Seattle, WA 98104, USADepartment of Medical Microbiology, University of Nairobi, P.O. Box 30197-00100, Nairobi, KenyaDepartment of Global Health, University of Washington, 325 9th Avenue, Seattle, WA 98104, USADepartment of Global Health, University of Washington, 325 9th Avenue, Seattle, WA 98104, USAHuman Biology Division, Fred Hutch Cancer Research Center, 1100 Fairview Ave N., Seattle, WA 98109, USAHIV-1 superinfection, in which an infected individual acquires a second HIV-1 infection from a different partner, is one of the only settings in which HIV acquisition occurs in the context of a pre-existing immune response to natural HIV infection. There is evidence that initial infection provides some protection from superinfection, particularly after 6 months of initial infection, when development of broad immunity occurs. Comparison of the immune response of superinfected individuals at the time of superinfection acquisition to that of individuals who remain singly infected despite continued exposure can shed light on immune correlates of HIV acquisition to inform prophylactic vaccine design. We evaluated a panel of humoral immune responses in the largest published group of superinfected individuals (n = 21), compared to a set of 3:1 matched singly infected controls from the same cohort. The immune functions studied included plasma neutralization, plasma and cervical antibody-dependent cellular cytotoxicity, and plasma IgG and IgA binding to a panel of 18 envelope antigens, including correlates of HIV acquisition in the RV144 vaccine trial, IgG binding to V1V2 and IgA binding to gp140. Association between each immune function and HIV superinfection was evaluated using conditional logistic regression. No significant associations were detected between any of the immune functions and superinfection acquisition. This study constitutes the most comprehensive and detailed characterization of multiple immune correlates of superinfection to date. The results suggest that immune responses not commonly measured in current HIV studies may be important in protection from HIV infection, and these or a more robust humoral response than that seen in naturally infected women may be needed for a protective vaccine.http://www.sciencedirect.com/science/article/pii/S2352396417301469HIVSuperinfectionAntibodyNeutralizationBindingImmune correlate |
| spellingShingle | Keshet Ronen Adam S. Dingens Susan M. Graham Walter Jaoko Kishor Mandaliya R. Scott McClelland Julie Overbaugh Comprehensive Characterization of Humoral Correlates of Human Immunodeficiency Virus 1 Superinfection Acquisition in High-risk Kenyan Women EBioMedicine HIV Superinfection Antibody Neutralization Binding Immune correlate |
| title | Comprehensive Characterization of Humoral Correlates of Human Immunodeficiency Virus 1 Superinfection Acquisition in High-risk Kenyan Women |
| title_full | Comprehensive Characterization of Humoral Correlates of Human Immunodeficiency Virus 1 Superinfection Acquisition in High-risk Kenyan Women |
| title_fullStr | Comprehensive Characterization of Humoral Correlates of Human Immunodeficiency Virus 1 Superinfection Acquisition in High-risk Kenyan Women |
| title_full_unstemmed | Comprehensive Characterization of Humoral Correlates of Human Immunodeficiency Virus 1 Superinfection Acquisition in High-risk Kenyan Women |
| title_short | Comprehensive Characterization of Humoral Correlates of Human Immunodeficiency Virus 1 Superinfection Acquisition in High-risk Kenyan Women |
| title_sort | comprehensive characterization of humoral correlates of human immunodeficiency virus 1 superinfection acquisition in high risk kenyan women |
| topic | HIV Superinfection Antibody Neutralization Binding Immune correlate |
| url | http://www.sciencedirect.com/science/article/pii/S2352396417301469 |
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