Intertemporal trade-off between population growth rate and carrying capacity during public good production
Summary: Public goods are biomolecules that benefit cellular populations, such as by providing access to previously unutilized resources. Public good production is energetically costly. To reduce this cost, populations control public good biosynthesis, for example using density-dependent regulation...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422200387X |
| _version_ | 1819050094302855168 |
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| author | Manasi S. Gangan Marcos M. Vasconcelos Urbashi Mitra Odilon Câmara James Q. Boedicker |
| author_facet | Manasi S. Gangan Marcos M. Vasconcelos Urbashi Mitra Odilon Câmara James Q. Boedicker |
| author_sort | Manasi S. Gangan |
| collection | DOAJ |
| description | Summary: Public goods are biomolecules that benefit cellular populations, such as by providing access to previously unutilized resources. Public good production is energetically costly. To reduce this cost, populations control public good biosynthesis, for example using density-dependent regulation accomplished by quorum sensing. Fitness costs and benefits of public good production must be balanced, similar to optimal investment decisions used in economics. We explore the regulation of a public good that increases the carrying capacity, through experimental measurements of growth in Escherichia coli and analysis using a modified logistic growth model. The timing of public good production showed a sharply peaked optimum in population fitness. The cell density associated with maximum public good benefits was determined by the trade-off between the cost of public good production, in terms of reduced growth rate, and benefits received from public goods, in the form of increased carrying capacity. |
| first_indexed | 2024-12-21T11:42:35Z |
| format | Article |
| id | doaj.art-b5495f05a77e40acb663653996315a38 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-21T11:42:35Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-b5495f05a77e40acb663653996315a382022-12-21T19:05:16ZengElsevieriScience2589-00422022-04-01254104117Intertemporal trade-off between population growth rate and carrying capacity during public good productionManasi S. Gangan0Marcos M. Vasconcelos1Urbashi Mitra2Odilon Câmara3James Q. Boedicker4Department of Physics and Astronomy, University of Southern California, Los Angeles, CA, USACommonweath Cyber-Initiative and Bradley Department of Electrical Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USAMing Hsieh Department of Electrical & Computer Engineering, Department of Computer Science, University of Southern California, Los Angeles, CA, USAUSC Marshall School of Business, University of Southern California, Los Angeles, CA, USADepartment of Physics and Astronomy, University of Southern California, Los Angeles, CA, USA; Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA; Corresponding authorSummary: Public goods are biomolecules that benefit cellular populations, such as by providing access to previously unutilized resources. Public good production is energetically costly. To reduce this cost, populations control public good biosynthesis, for example using density-dependent regulation accomplished by quorum sensing. Fitness costs and benefits of public good production must be balanced, similar to optimal investment decisions used in economics. We explore the regulation of a public good that increases the carrying capacity, through experimental measurements of growth in Escherichia coli and analysis using a modified logistic growth model. The timing of public good production showed a sharply peaked optimum in population fitness. The cell density associated with maximum public good benefits was determined by the trade-off between the cost of public good production, in terms of reduced growth rate, and benefits received from public goods, in the form of increased carrying capacity.http://www.sciencedirect.com/science/article/pii/S258900422200387XComputational molecular modelingMicrobiology |
| spellingShingle | Manasi S. Gangan Marcos M. Vasconcelos Urbashi Mitra Odilon Câmara James Q. Boedicker Intertemporal trade-off between population growth rate and carrying capacity during public good production iScience Computational molecular modeling Microbiology |
| title | Intertemporal trade-off between population growth rate and carrying capacity during public good production |
| title_full | Intertemporal trade-off between population growth rate and carrying capacity during public good production |
| title_fullStr | Intertemporal trade-off between population growth rate and carrying capacity during public good production |
| title_full_unstemmed | Intertemporal trade-off between population growth rate and carrying capacity during public good production |
| title_short | Intertemporal trade-off between population growth rate and carrying capacity during public good production |
| title_sort | intertemporal trade off between population growth rate and carrying capacity during public good production |
| topic | Computational molecular modeling Microbiology |
| url | http://www.sciencedirect.com/science/article/pii/S258900422200387X |
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