Emerging Role of microRNAs and Long Non-Coding RNAs in Sjögren’s Syndrome
Sjögren’s Syndrome (SS) is a chronic autoimmune inflammatory disease. It is considered a multifactorial pathology, in which underlying genetic predisposition, epigenetic mechanisms and environmental factors contribute to development. The epigenetic regulations represent a link between genetic predis...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/6/903 |
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| author | Giada De Benedittis Cinzia Ciccacci Andrea Latini Lucia Novelli Giuseppe Novelli Paola Borgiani |
| author_facet | Giada De Benedittis Cinzia Ciccacci Andrea Latini Lucia Novelli Giuseppe Novelli Paola Borgiani |
| author_sort | Giada De Benedittis |
| collection | DOAJ |
| description | Sjögren’s Syndrome (SS) is a chronic autoimmune inflammatory disease. It is considered a multifactorial pathology, in which underlying genetic predisposition, epigenetic mechanisms and environmental factors contribute to development. The epigenetic regulations represent a link between genetic predisposition and environmental factors. Recent studies suggested a regulatory role for non-coding RNAs in critical biological and disease processes. Among non-coding RNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) play a critical role in the post-transcriptional mRNA expression, forming a complex network of gene expression regulation. This review aims to give an overview of the latest studies that have investigated the role of miRNAs and lncRNAs in the SS. We included papers that investigated the expression of non-coding RNAs on different tissues, in particular on peripheral blood mononuclear cells and salivary glands. However, regarding the involvement of non-coding RNAs genetic variability in SS susceptibility very few data are available. Further research could help to elucidate underlying pathogenic processes of SS and provide new opportunities for the development of targeted therapies. |
| first_indexed | 2024-03-10T10:30:34Z |
| format | Article |
| id | doaj.art-b54a35f1c6814d82afb825d8422cbdf9 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T10:30:34Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-b54a35f1c6814d82afb825d8422cbdf92023-11-21T23:42:06ZengMDPI AGGenes2073-44252021-06-0112690310.3390/genes12060903Emerging Role of microRNAs and Long Non-Coding RNAs in Sjögren’s SyndromeGiada De Benedittis0Cinzia Ciccacci1Andrea Latini2Lucia Novelli3Giuseppe Novelli4Paola Borgiani5Department of Biomedicine & Prevention, Genetics Section, University of Rome Tor Vergata, 00133 Rome, ItalyUniCamillus–Saint Camillus International University of Health Sciences, 00131 Rome, ItalyDepartment of Biomedicine & Prevention, Genetics Section, University of Rome Tor Vergata, 00133 Rome, ItalyUniCamillus–Saint Camillus International University of Health Sciences, 00131 Rome, ItalyDepartment of Biomedicine & Prevention, Genetics Section, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine & Prevention, Genetics Section, University of Rome Tor Vergata, 00133 Rome, ItalySjögren’s Syndrome (SS) is a chronic autoimmune inflammatory disease. It is considered a multifactorial pathology, in which underlying genetic predisposition, epigenetic mechanisms and environmental factors contribute to development. The epigenetic regulations represent a link between genetic predisposition and environmental factors. Recent studies suggested a regulatory role for non-coding RNAs in critical biological and disease processes. Among non-coding RNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) play a critical role in the post-transcriptional mRNA expression, forming a complex network of gene expression regulation. This review aims to give an overview of the latest studies that have investigated the role of miRNAs and lncRNAs in the SS. We included papers that investigated the expression of non-coding RNAs on different tissues, in particular on peripheral blood mononuclear cells and salivary glands. However, regarding the involvement of non-coding RNAs genetic variability in SS susceptibility very few data are available. Further research could help to elucidate underlying pathogenic processes of SS and provide new opportunities for the development of targeted therapies.https://www.mdpi.com/2073-4425/12/6/903Sjögren’s SyndromemicroRNAslong non-coding RNAs |
| spellingShingle | Giada De Benedittis Cinzia Ciccacci Andrea Latini Lucia Novelli Giuseppe Novelli Paola Borgiani Emerging Role of microRNAs and Long Non-Coding RNAs in Sjögren’s Syndrome Genes Sjögren’s Syndrome microRNAs long non-coding RNAs |
| title | Emerging Role of microRNAs and Long Non-Coding RNAs in Sjögren’s Syndrome |
| title_full | Emerging Role of microRNAs and Long Non-Coding RNAs in Sjögren’s Syndrome |
| title_fullStr | Emerging Role of microRNAs and Long Non-Coding RNAs in Sjögren’s Syndrome |
| title_full_unstemmed | Emerging Role of microRNAs and Long Non-Coding RNAs in Sjögren’s Syndrome |
| title_short | Emerging Role of microRNAs and Long Non-Coding RNAs in Sjögren’s Syndrome |
| title_sort | emerging role of micrornas and long non coding rnas in sjogren s syndrome |
| topic | Sjögren’s Syndrome microRNAs long non-coding RNAs |
| url | https://www.mdpi.com/2073-4425/12/6/903 |
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