The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk
Abstract Introduction A brief, easily calculated and interpretable index to assess vulnerability to developing cognitive impairment is needed in clinical practice and research. To address this, we developed the Vulnerability Index (VI) with the goal of identifying individuals possessing a high risk...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12249 |
| _version_ | 1797975542938468352 |
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| author | Michael J. Kleiman James E. Galvin |
| author_facet | Michael J. Kleiman James E. Galvin |
| author_sort | Michael J. Kleiman |
| collection | DOAJ |
| description | Abstract Introduction A brief, easily calculated and interpretable index to assess vulnerability to developing cognitive impairment is needed in clinical practice and research. To address this, we developed the Vulnerability Index (VI) with the goal of identifying individuals possessing a high risk for cognitive impairment. Methods Twelve easily obtained sociodemographic, medical, and functional factors were used to develop the VI, with each selectively weighted based on factor analysis and predictive modeling. This cross‐sectional study examined 387 subject‐partner dyads. Results The VI was found to accurately discriminate between cognitively normal controls and participants with cognitive impairment (area under the curve [AUC]: 0.844; 95% confidence interval [CI]: 0.776‐0.913) and individuals scoring high on the VI (≥8) had worse health, functional, behavioral, cognitive, and quality of life ratings than those with lower scores. Discussion The VI could be used in screening asymptomatic individuals for risk of cognitive impairment and guiding the development of primary and secondary prevention plans. |
| first_indexed | 2024-04-11T04:37:12Z |
| format | Article |
| id | doaj.art-b54a8f8ffbbe466a95647ae4c3aed5dd |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-04-11T04:37:12Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-b54a8f8ffbbe466a95647ae4c3aed5dd2022-12-28T09:12:13ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292021-01-01131n/an/a10.1002/dad2.12249The Vulnerability Index: A weighted measure of dementia and cognitive impairment riskMichael J. Kleiman0James E. Galvin1Comprehensive Center for Brain Health Department of Neurology University of Miami Miller School of Medicine Boca Raton Florida USAComprehensive Center for Brain Health Department of Neurology University of Miami Miller School of Medicine Boca Raton Florida USAAbstract Introduction A brief, easily calculated and interpretable index to assess vulnerability to developing cognitive impairment is needed in clinical practice and research. To address this, we developed the Vulnerability Index (VI) with the goal of identifying individuals possessing a high risk for cognitive impairment. Methods Twelve easily obtained sociodemographic, medical, and functional factors were used to develop the VI, with each selectively weighted based on factor analysis and predictive modeling. This cross‐sectional study examined 387 subject‐partner dyads. Results The VI was found to accurately discriminate between cognitively normal controls and participants with cognitive impairment (area under the curve [AUC]: 0.844; 95% confidence interval [CI]: 0.776‐0.913) and individuals scoring high on the VI (≥8) had worse health, functional, behavioral, cognitive, and quality of life ratings than those with lower scores. Discussion The VI could be used in screening asymptomatic individuals for risk of cognitive impairment and guiding the development of primary and secondary prevention plans.https://doi.org/10.1002/dad2.12249Alzheimer's diseasecognitive impairmentdementiafunctional assessmentshealth recordsprimary prevention |
| spellingShingle | Michael J. Kleiman James E. Galvin The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease cognitive impairment dementia functional assessments health records primary prevention |
| title | The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk |
| title_full | The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk |
| title_fullStr | The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk |
| title_full_unstemmed | The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk |
| title_short | The Vulnerability Index: A weighted measure of dementia and cognitive impairment risk |
| title_sort | vulnerability index a weighted measure of dementia and cognitive impairment risk |
| topic | Alzheimer's disease cognitive impairment dementia functional assessments health records primary prevention |
| url | https://doi.org/10.1002/dad2.12249 |
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