Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective
Vitreoretinal surgeries for ocular diseases such as complicated retinal detachment, diabetic retinopathy, macular holes and ocular trauma has led to the development of various tamponades over the years in search for an ideal vitreous substitute. Current clinically used tamponade agents such as air,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/1/121 |
| _version_ | 1797543038140022784 |
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| author | Minal Thacker Ching-Li Tseng Feng-Huei Lin |
| author_facet | Minal Thacker Ching-Li Tseng Feng-Huei Lin |
| author_sort | Minal Thacker |
| collection | DOAJ |
| description | Vitreoretinal surgeries for ocular diseases such as complicated retinal detachment, diabetic retinopathy, macular holes and ocular trauma has led to the development of various tamponades over the years in search for an ideal vitreous substitute. Current clinically used tamponade agents such as air, perfluorocarbons, silicone oil and expansile gases serve only as a short-term solution and harbors various disadvantages. However, an ideal long-term substitute is yet to be discovered and recent research emphasizes on the potential of polymeric hydrogels as an ideal vitreous substitute. This review highlights the recent progress in the field of vitreous substitution. Suitability and adverse effects of various tamponade agents in present day clinical use and biomaterials in the experimental phase have been outlined and discussed. In addition, we introduced the anatomy and functions of the native vitreous body and the pathological conditions which require vitreous replacement. |
| first_indexed | 2024-03-10T13:39:58Z |
| format | Article |
| id | doaj.art-b54af3d8cb0b4b249a8ffbb4bba4beb4 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T13:39:58Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-b54af3d8cb0b4b249a8ffbb4bba4beb42023-11-21T03:10:25ZengMDPI AGPolymers2073-43602020-12-0113112110.3390/polym13010121Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future ProspectiveMinal Thacker0Ching-Li Tseng1Feng-Huei Lin2Graduate Institute of Biomedical Engineering, National Taiwan University, Daan District, Taipei 10051, TaiwanGraduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei 11031, TaiwanGraduate Institute of Biomedical Engineering, National Taiwan University, Daan District, Taipei 10051, TaiwanVitreoretinal surgeries for ocular diseases such as complicated retinal detachment, diabetic retinopathy, macular holes and ocular trauma has led to the development of various tamponades over the years in search for an ideal vitreous substitute. Current clinically used tamponade agents such as air, perfluorocarbons, silicone oil and expansile gases serve only as a short-term solution and harbors various disadvantages. However, an ideal long-term substitute is yet to be discovered and recent research emphasizes on the potential of polymeric hydrogels as an ideal vitreous substitute. This review highlights the recent progress in the field of vitreous substitution. Suitability and adverse effects of various tamponade agents in present day clinical use and biomaterials in the experimental phase have been outlined and discussed. In addition, we introduced the anatomy and functions of the native vitreous body and the pathological conditions which require vitreous replacement.https://www.mdpi.com/2073-4360/13/1/121vitreous substitutebiopolymer |
| spellingShingle | Minal Thacker Ching-Li Tseng Feng-Huei Lin Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective Polymers vitreous substitute biopolymer |
| title | Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective |
| title_full | Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective |
| title_fullStr | Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective |
| title_full_unstemmed | Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective |
| title_short | Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective |
| title_sort | substitutes and colloidal system for vitreous replacement and drug delivery recent progress and future prospective |
| topic | vitreous substitute biopolymer |
| url | https://www.mdpi.com/2073-4360/13/1/121 |
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