The Clinicopathological and Prognostic Implications of FoxP3+ Regulatory T Cells in Patients with Colorectal Cancer: A Meta-Analysis
Background and Objective: Forkhead box P3 (FoxP3) is known as the specific marker for regulatory T lymphocytes (Tregs), which are responsible for self-tolerance and disturb the antitumor immunity. However, the prognostic implication of tumor-infiltrating FoxP3+ Tregs in patients with colorectal canc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2017.00950/full |
| _version_ | 1818137503794724864 |
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| author | Peipei Xu Wei Fan Wei Fan Zheng Zhang June Wang Ping Wang Yirong Li Mingxia Yu |
| author_facet | Peipei Xu Wei Fan Wei Fan Zheng Zhang June Wang Ping Wang Yirong Li Mingxia Yu |
| author_sort | Peipei Xu |
| collection | DOAJ |
| description | Background and Objective: Forkhead box P3 (FoxP3) is known as the specific marker for regulatory T lymphocytes (Tregs), which are responsible for self-tolerance and disturb the antitumor immunity. However, the prognostic implication of tumor-infiltrating FoxP3+ Tregs in patients with colorectal cancer (CRC) still remains controversial. The aim of this present study was to investigate the prognostic role of FoxP3+ Tregs in CRC through meta-analysis.Methods: PubMed, Embase and Web of Science were searched for relevant articles up to December 12, 2016. Pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated to explore the prognostic value of FoxP3+ Tregs in CRC. Odds ratio (OR) was calculated to investigate the correlation between FoxP3+ Tregs and pathological parameters.Results: A total of 18 studies comprising 3,627 patients with CRC were enrolled in our meta-analysis. The combined HR for FoxP3+ Tregs on cancer-specific survival was 0.70 (95% CI = 0.62–0.80, P < 0.001). High FoxP3+ Tregs level was also associated with favorable prognosis on overall survival (HR = 0.76, 95% CI = 0.58–1.01, P = 0.058), with P-value very close to the statistical threshold. Yet, there was no correlation between FoxP3+ Tregs infiltration and disease-free survival (HR = 0.83, 95% CI = 0.63–1.09, P = 0.182). Moreover, FoxP3+ Tregs infiltration was significantly correlated with pT stage (OR = 0.50, 95% CI = 0.39–0.65, P < 0.001), tumor grade (OR = 0.77, 95% CI = 0.61–0.98, P = 0.032), lymphatic invasion (OR = 0.25, 95% CI = 0.07–0.89, P = 0.033) and vascular invasion (OR = 0.67, 95% CI = 0.52–0.86, P = 0.001).Conclusion: The present meta-analysis suggests that high FoxP3+ Tregs infiltration is inclined to indicate favorable prognosis and is associated with the pathogenesis of CRC. Immunotherapy targeting Tregs in patients with CRC should be further investigated. |
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| id | doaj.art-b54c0eb7e71e42c19c52cfdc27d982a6 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-11T09:57:21Z |
| publishDate | 2017-11-01 |
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| series | Frontiers in Physiology |
| spelling | doaj.art-b54c0eb7e71e42c19c52cfdc27d982a62022-12-22T01:12:15ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-11-01810.3389/fphys.2017.00950282612The Clinicopathological and Prognostic Implications of FoxP3+ Regulatory T Cells in Patients with Colorectal Cancer: A Meta-AnalysisPeipei Xu0Wei Fan1Wei Fan2Zheng Zhang3June Wang4Ping Wang5Yirong Li6Mingxia Yu7Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, ChinaBackground and Objective: Forkhead box P3 (FoxP3) is known as the specific marker for regulatory T lymphocytes (Tregs), which are responsible for self-tolerance and disturb the antitumor immunity. However, the prognostic implication of tumor-infiltrating FoxP3+ Tregs in patients with colorectal cancer (CRC) still remains controversial. The aim of this present study was to investigate the prognostic role of FoxP3+ Tregs in CRC through meta-analysis.Methods: PubMed, Embase and Web of Science were searched for relevant articles up to December 12, 2016. Pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated to explore the prognostic value of FoxP3+ Tregs in CRC. Odds ratio (OR) was calculated to investigate the correlation between FoxP3+ Tregs and pathological parameters.Results: A total of 18 studies comprising 3,627 patients with CRC were enrolled in our meta-analysis. The combined HR for FoxP3+ Tregs on cancer-specific survival was 0.70 (95% CI = 0.62–0.80, P < 0.001). High FoxP3+ Tregs level was also associated with favorable prognosis on overall survival (HR = 0.76, 95% CI = 0.58–1.01, P = 0.058), with P-value very close to the statistical threshold. Yet, there was no correlation between FoxP3+ Tregs infiltration and disease-free survival (HR = 0.83, 95% CI = 0.63–1.09, P = 0.182). Moreover, FoxP3+ Tregs infiltration was significantly correlated with pT stage (OR = 0.50, 95% CI = 0.39–0.65, P < 0.001), tumor grade (OR = 0.77, 95% CI = 0.61–0.98, P = 0.032), lymphatic invasion (OR = 0.25, 95% CI = 0.07–0.89, P = 0.033) and vascular invasion (OR = 0.67, 95% CI = 0.52–0.86, P = 0.001).Conclusion: The present meta-analysis suggests that high FoxP3+ Tregs infiltration is inclined to indicate favorable prognosis and is associated with the pathogenesis of CRC. Immunotherapy targeting Tregs in patients with CRC should be further investigated.http://journal.frontiersin.org/article/10.3389/fphys.2017.00950/fullcolorectal cancerFoxP3+ regulatory T lymphocytesclinicopathological featuresprognostic implicationsmeta-analysis |
| spellingShingle | Peipei Xu Wei Fan Wei Fan Zheng Zhang June Wang Ping Wang Yirong Li Mingxia Yu The Clinicopathological and Prognostic Implications of FoxP3+ Regulatory T Cells in Patients with Colorectal Cancer: A Meta-Analysis Frontiers in Physiology colorectal cancer FoxP3+ regulatory T lymphocytes clinicopathological features prognostic implications meta-analysis |
| title | The Clinicopathological and Prognostic Implications of FoxP3+ Regulatory T Cells in Patients with Colorectal Cancer: A Meta-Analysis |
| title_full | The Clinicopathological and Prognostic Implications of FoxP3+ Regulatory T Cells in Patients with Colorectal Cancer: A Meta-Analysis |
| title_fullStr | The Clinicopathological and Prognostic Implications of FoxP3+ Regulatory T Cells in Patients with Colorectal Cancer: A Meta-Analysis |
| title_full_unstemmed | The Clinicopathological and Prognostic Implications of FoxP3+ Regulatory T Cells in Patients with Colorectal Cancer: A Meta-Analysis |
| title_short | The Clinicopathological and Prognostic Implications of FoxP3+ Regulatory T Cells in Patients with Colorectal Cancer: A Meta-Analysis |
| title_sort | clinicopathological and prognostic implications of foxp3 regulatory t cells in patients with colorectal cancer a meta analysis |
| topic | colorectal cancer FoxP3+ regulatory T lymphocytes clinicopathological features prognostic implications meta-analysis |
| url | http://journal.frontiersin.org/article/10.3389/fphys.2017.00950/full |
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