Neuropeptides and the Nodes of Ranvier in Cranial Headaches
The trigeminovascular system (TGV) comprise of the trigeminal ganglion with neurons and satellite glial cells, with sensory unmyelinated C-fibers and myelinated Aδ-fibers picking up information from different parts of the head and sending signals to the brainstem and the central nervous system. In t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.820037/full |
| _version_ | 1798020408166842368 |
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| author | Jacob C. A. Edvinsson Jacob C. A. Edvinsson Kristian A. Haanes Lars Edvinsson Lars Edvinsson |
| author_facet | Jacob C. A. Edvinsson Jacob C. A. Edvinsson Kristian A. Haanes Lars Edvinsson Lars Edvinsson |
| author_sort | Jacob C. A. Edvinsson |
| collection | DOAJ |
| description | The trigeminovascular system (TGV) comprise of the trigeminal ganglion with neurons and satellite glial cells, with sensory unmyelinated C-fibers and myelinated Aδ-fibers picking up information from different parts of the head and sending signals to the brainstem and the central nervous system. In this review we discuss aspects of signaling at the distal parts of the sensory fibers, the extrasynaptic signaling between C-fibers and Aδ-fibers, and the contact between the trigeminal fibers at the nerve root entry zone where they transit into the CNS. We also address the possible role of the neuropeptides calcitonin gene-related peptide (CGRP), the neurokinin family and pituitary adenylyl cyclase-activating polypeptide 38 (PACAP-38), all found in the TGV system together with their respective receptors. Elucidation of the expression and localization of neuropeptides and their receptors in the TGV system may provide novel ways to understand their roles in migraine pathophysiology and suggest novel ways for treatment of migraine patients. |
| first_indexed | 2024-04-11T16:57:01Z |
| format | Article |
| id | doaj.art-b54ca7296315479896686c2b84310488 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-11T16:57:01Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-b54ca7296315479896686c2b843104882022-12-22T04:13:14ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-01-011210.3389/fphys.2021.820037820037Neuropeptides and the Nodes of Ranvier in Cranial HeadachesJacob C. A. Edvinsson0Jacob C. A. Edvinsson1Kristian A. Haanes2Lars Edvinsson3Lars Edvinsson4Department of Clinical Experimental Research, Rigshospitalet-Glostrup, Copenhagen, DenmarkDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, DenmarkDepartment of Clinical Experimental Research, Rigshospitalet-Glostrup, Copenhagen, DenmarkDepartment of Clinical Experimental Research, Rigshospitalet-Glostrup, Copenhagen, DenmarkDepartment of Internal Medicine, Lund University, Lund, SwedenThe trigeminovascular system (TGV) comprise of the trigeminal ganglion with neurons and satellite glial cells, with sensory unmyelinated C-fibers and myelinated Aδ-fibers picking up information from different parts of the head and sending signals to the brainstem and the central nervous system. In this review we discuss aspects of signaling at the distal parts of the sensory fibers, the extrasynaptic signaling between C-fibers and Aδ-fibers, and the contact between the trigeminal fibers at the nerve root entry zone where they transit into the CNS. We also address the possible role of the neuropeptides calcitonin gene-related peptide (CGRP), the neurokinin family and pituitary adenylyl cyclase-activating polypeptide 38 (PACAP-38), all found in the TGV system together with their respective receptors. Elucidation of the expression and localization of neuropeptides and their receptors in the TGV system may provide novel ways to understand their roles in migraine pathophysiology and suggest novel ways for treatment of migraine patients.https://www.frontiersin.org/articles/10.3389/fphys.2021.820037/fulltrigeminal ganglionnodes of RanvierRemak bundlesvascular neuroeffector sitenerve entry zoneRedlich-Obersteiner zone |
| spellingShingle | Jacob C. A. Edvinsson Jacob C. A. Edvinsson Kristian A. Haanes Lars Edvinsson Lars Edvinsson Neuropeptides and the Nodes of Ranvier in Cranial Headaches Frontiers in Physiology trigeminal ganglion nodes of Ranvier Remak bundles vascular neuroeffector site nerve entry zone Redlich-Obersteiner zone |
| title | Neuropeptides and the Nodes of Ranvier in Cranial Headaches |
| title_full | Neuropeptides and the Nodes of Ranvier in Cranial Headaches |
| title_fullStr | Neuropeptides and the Nodes of Ranvier in Cranial Headaches |
| title_full_unstemmed | Neuropeptides and the Nodes of Ranvier in Cranial Headaches |
| title_short | Neuropeptides and the Nodes of Ranvier in Cranial Headaches |
| title_sort | neuropeptides and the nodes of ranvier in cranial headaches |
| topic | trigeminal ganglion nodes of Ranvier Remak bundles vascular neuroeffector site nerve entry zone Redlich-Obersteiner zone |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.820037/full |
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