RhoA/ROCK signalling activated by ARHGEF3 promotes muscle weakness via autophagy in dystrophic mdx mice

RhoA/ROCK signalling activated by ARHGEF3 promotes muscle weakness via autophagy in dystrophic mdx mice

Abstract Background Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, leads to progressive and fatal muscle weakness through yet‐to‐be‐fully deciphered molecular perturbations. Emerging evidence implicates RhoA/Rho‐associated protein kinase (ROCK) signalling in DMD pathology, yet i...

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Bibliographic Details
Main Authors: Jae‐Sung You, Yongdeok Kim, Soohyun Lee, Rashid Bashir, Jie Chen
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Mdx
Engineered muscle
Force
Regeneration
XPLN
Chloroquine
Online Access:https://doi.org/10.1002/jcsm.13278

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